Archive for the ‘Bayer’ Category
Posted by kinasepro on May 20, 2009
The distinct compound is claimed in WO/2005/009961 and the I believe the original Sorafenib app is: WO/2000/042012. What strikes the chemist inventor about a structure like this isn’t usually about who owns it, but if it can really be considered a new invention? The claim structure in the 2000 Sorafenib application can be schematized:
Anyhow while this structure and their priority date may be vulnerable to obviousness, all of these applications are assigned to Bayer, and not Onyx, so that disagreement will more likely be resolved based on the wording of the Onyx / Bayer contract. The Onyx press release suggests this very structure was discovered during the collaboration… We’ll see. Given the timing I bet someone saw the structure here on Kinasepro and told Onyx, heh.
Posted by kinasepro on April 29, 2009
Posted by kinasepro on April 7, 2009
It’s Bayer’s Ph2 follow-on to Sorafenib. VEGF / RAF yadda yadda… Don’t have the structure, but maybe it’s one of these:
from polymorph apps:
& yeh, that is Fluoro-Nexavar…
Posted by kinasepro on October 2, 2007
Set of covalent ErbB inhibitors from Bayer:
Posted by kinasepro on May 18, 2007
The ontology of WO/2007/056170 seems pretty clear, and given the lack of a BMCL even though everybody got laid off they’re probably moving a compound forward.
Oh yah, and Derek: Welcome to the dark side.
Posted by kinasepro on April 8, 2007
Nexavar ®, sorafenib tosylate, BAY-439006
Discovery: Bayer WO/2000/042012
US Approval: December 2005
Posted by kinasepro on November 9, 2006
In case you’ve been under a rock today, Bayer is closing both its West Haven, CT site and Schering’s Richmond, CA site. They claim the number is 800, but estimates put the Richmond site at 380, and the CT site at 1,100. They either plan on relocating 600 people or they are lieing.
This is an unhappy day in KinaseLand.