Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Uncategorized’ Category


Posted by kinasepro on October 29, 2006

and DE102005020105. Guten Tag Schering AG,

Further along the road with the thiazolidinones, eh?  I like the title: New thiazolidinone without basic nitrogen, their production and use as drugs

Kinasepro is always happy to see more Plk1 inhibitors, but hey I’ll admit that I haven’t a clue whats going on with these – and now consider an earlier post on your analogous series, ummm, wrong. The only PDBs that give KP a hint as to what could be going on here are from some compounds bound to PI3K: 2A4Z, and 2A5U. O=C(N(CC)/C(S2)=C(C(NCC(F)(F)F)=O)\C#N)/C2=C/C1=C(C)N=CN1 O=C(N(CC)/C(S2)=C(C(NCC#C)=O)\C#N)/C2=C/C1=CC=C(N3CCCC3)C=C1

Posted in Plk1, Schering AG, Uncategorized | Leave a Comment »


Posted by kinasepro on October 14, 2006

So Kinasepro’s homework for the evening was to catch up on some of the PLK1 application literature just to see what’s out there. Expecting to see some Schering rip-offs, I was surprised to find a robust cast of characters playing there parts on the Polo-like stage.

Structurally it appears that there’s a cystein residue on the inside of the p-loop which most of these applications appear to attempt to exploit in one fasion or another.

Don’t care about PLK1? Then you may want to check back in a bit…

Posted in Plk1, Uncategorized | Leave a Comment »

Did you know?

Posted by kinasepro on October 12, 2006

There’s apparantly a journal called: Expert Opinion on Therapeutic Patents.
And has been since 1990… Yah, me neither. I guess I can close my new blog then, Eh?

Posted in Uncategorized | Leave a Comment »


Posted by kinasepro on October 2, 2006

Inspired by better men, the likes of Tenderbutton, Milkshake, and Lowe, I’m actually going to try and get this bird off the ground.

Posted in Uncategorized | Leave a Comment »