Archive for the ‘CDK’ Category
Posted by kinasepro on March 27, 2009
Posted by kinasepro on October 1, 2008
Hey look what I got:
Yah, its the disclosure of the discovery of PHA-848125. Not only that, its a pretty good poster. This also means I was wrong again!
Posted by kinasepro on November 23, 2007
Astex’s fragment based discovery effort yielded an oral candidate back in ’05, and now with WO/2007/129066 & WO/2007/129062 the world can have a look. It’s probably AT-9311 even though I could’a swore I heard’m say that their Novartis’ partnered material was of a different series then AT-7519. Perhaps its 7519 I have wrong…
|0.22 uM GSK3b|
|Mouse: 40-50%F (DMSO/Water/PEG 1/2/7)|
Posted by kinasepro on August 19, 2007
>> Update >> its really PHA-848125
WO/2007/90794 is a CDK inhibitor in combination with yada yada… from Nerviano. The single compound claimed is pictured and potentially the phase one compound: PHA-793887.
Discovery: Pharmacia IT WO/2004/104007
Posted by kinasepro on July 16, 2007
In our study, we employ mice to show that extinction of learned fear depends on counteracting components of a molecular pathway involving the protein kinase Cdk5