KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Millenium’ Category

MLN-0415

Posted by kinasepro on May 2, 2009

Millenium’s beta-carboline’s aren’t new, but the structure of the Phase one IKK-B inhibitor hasn’t been released afaik.  Currrently in the Takeda pipeline via last years takeover.

ClC1=CC(NC([C@H]2N(CC(C)(OC2)C)CC(N3C[C@H](O[C@H](C3)C)C)=O)=O)=C(C4=C1)NC5=C4C=CN=C5WO/2009/054970

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Posted in IKK, Millenium, Takeda | Leave a Comment »

RAF a la MLNM

Posted by kinasepro on July 4, 2007

US20070149533 is a Raf app from Millennium. I see it as a napthalene – amide cousin to the Birb and Nexavar style ureas. Amgen’s been in the area but not right on top.

O=C(CCN1CCN(C)CC1)NC2=NC=CC(OC3=CC(C=CC(C(NC4=CC(C(C)(C)C)=CC=C4)=O)=C5)=C5C=C3)=C2

Good thing too, b/c you know, I was’t really feeling the whole ‘hydrocinnamides’ thing in US20060160803

Posted in Millenium, RAF | Leave a Comment »

Millennium’s Aurora Compounds

Posted by kinasepro on June 12, 2007

So Millennium is advancing MLN-8237 to phase one, but if the structure I have for MLN-8054 is correct:

O=C(O)C1=CC=C(NC2=NC=C3CN=C(C4=C(F)C=CC=C4F)C5=CC(Cl)=CC=C5C3=N2)C=C1

… then I’m crossing my fingers that MLN-8237 isn’t the methyl ester! All I can find is: US/2005/0256102.

Posted in Aurora, Millenium | 4 Comments »