Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Trk’ Category


Posted by kinasepro on May 28, 2007


Lestaurtinib / CEP-701 is currently in trials for a handful of indications and first appeared in WO/1988/07045 (US,4,923,986) via Kyowa Hakko Kogyo. The series was first described as a group of PKC inhibitors, but later came this ’98 press release: (emphasis mine)

CEP-701 is one of a series of specific receptor trk kinase inhibitor derived from the indolocarbazole K252a, which was originally synthesized by Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan

Read the rest of this entry »

Posted in c-Met, Cephalon, Flt3, JAK, Trk, VEGF | 3 Comments »

AZ’s got TrkA

Posted by kinasepro on February 22, 2007

I haven’t read it, but Cephalon’s got an Expert Opinion on the Array Biopharma / AstraZeneca’s Trk-A applications: WO06087538, WO06087530

OC[C@@H](C1=CC=C(F)C=C1)N2C=NC3=CC(Cl)=C(NC4=NNC(C5CC5)=C4)N=C32 C[C@@H](NC1=NC2=C(N=C([H])N2C3=NNC(C4CC4)=C3)C=N1)C5=CC=C(F)C=C5

In the series there’s also: WO/2006/082392


Cephalon’s got a staurosporine analog CEP-701 that hits the kinome, err I mean Vegfr-2, FLT-3, Trk-A and JAK-2 in ph3 trials for AML.

Bonus Link: Multi-Targeted Therapy = nice site.

Posted in Array, Astra, Trk | Leave a Comment »


Posted by kinasepro on January 5, 2007

These are part of a Flt3 and/or TrkB series which JnJ has been putting a beat down on lately.


Posted in Flt3, J&J, Trk | Leave a Comment »