KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Trk’ Category

Lestaurtinib

Posted by kinasepro on May 28, 2007

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Lestaurtinib / CEP-701 is currently in trials for a handful of indications and first appeared in WO/1988/07045 (US,4,923,986) via Kyowa Hakko Kogyo. The series was first described as a group of PKC inhibitors, but later came this ’98 press release: (emphasis mine)

CEP-701 is one of a series of specific receptor trk kinase inhibitor derived from the indolocarbazole K252a, which was originally synthesized by Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan

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Posted in c-Met, Cephalon, Flt3, JAK, Trk, VEGF | 3 Comments »

AZ’s got TrkA

Posted by kinasepro on February 22, 2007

I haven’t read it, but Cephalon’s got an Expert Opinion on the Array Biopharma / AstraZeneca’s Trk-A applications: WO06087538, WO06087530

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In the series there’s also: WO/2006/082392

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Cephalon’s got a staurosporine analog CEP-701 that hits the kinome, err I mean Vegfr-2, FLT-3, Trk-A and JAK-2 in ph3 trials for AML.

Bonus Link: Multi-Targeted Therapy = nice site.

Posted in Array, Astra, Trk | Leave a Comment »

US20070004763

Posted by kinasepro on January 5, 2007

These are part of a Flt3 and/or TrkB series which JnJ has been putting a beat down on lately.

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Posted in Flt3, J&J, Trk | Leave a Comment »