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Archive for the ‘PDB’ Category

3H9F

Posted by kinasepro on May 18, 2009

Normally…

3H9Fr

an A-loop doesn’t do that! (its new SGC prerelease of  a BI-PLK1-like inhibitor bound to TTK)

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Posted in PDB, SGC | Leave a Comment »

Nilotinib & P38ß

Posted by kinasepro on April 6, 2009

If you’ve got an IC50 comment here or email me:  SGC’s got a new pre-release.

 O=C(C1=CC=C(C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C)NC4=CC(C(F)(F)F)=CC(N5C=C(N=C5)C)=C4

p38ß = MAPK11 (not to be confused w/ p38α) 3GP0

Posted in p38, PDB | 1 Comment »

CP-690,550

Posted by kinasepro on February 10, 2009

CP-690,550 is Pfizer’s Ph3 Jak inhibitor. J Mol Biol. JAK2: 3FUP & JAK1?: 3EYG

N#CCC(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)=O

Thanks Cytopia & no I didn’t forget 3EYH

Posted in JAK, PDB | 3 Comments »

Whats that doin there?

Posted by kinasepro on January 20, 2009

Looks like Merck’s released an allosteric CHK1 pdb: 3F9N

3F9N

3F9N

Read the rest of this entry »

Posted in Chk1, PDB | 1 Comment »

PDB Update

Posted by kinasepro on October 29, 2008

Aurora A + 680: 3E5A; Protien Sci

Aurora B: 2VGO; Mol Cell Ther

SRC: 3EL7 & 3EL8; Chem Biol;

EPHB4: 2VWX; 2VWY; 2VX0, 2VX1

Posted in Aurora, EphB4, PDB, SRC | 2 Comments »

SGC’s got…

Posted by kinasepro on October 17, 2008

Lots ‘o’ new stuff

DYRK1A: 2VX3


Haspin: 3E7V, 2VUW, 3DLZ

v-FES + SS: 3CD3,3CBL,3BKB; CELL

Posted in PDB, SGC | Leave a Comment »

Plethora ‘o’ PDB’s

Posted by kinasepro on October 14, 2008

GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP

SGX: Jak2 3E64, 3E63, 3E62, BMCL

Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma

reminds me of OSI-906 or vice versa

Astrazeneca: CDK2 BMCL: 2W05

Amgen: P38 J Med Chem; 3DT1

LCK: 2ZM4, 2ZM1

Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »

PDB Update

Posted by kinasepro on October 7, 2008

Buncha-new Plk1 PDB’s

Plk1: 3DBF, 3DBE, 3DBD, 3DBC, 3DB8

new c-Met: 3EFK, 3EFJ

new Vegf: 3CJG, 3CJF

Posted in c-Met, PDB, Plk1, VEGF | Leave a Comment »

A new PI3K PDB

Posted by kinasepro on September 2, 2008

UCB published they’re spin on LY-294002: 3DPD: BMCL

see also: 1E7V

Posted in biotech, PDB, pi3k | Leave a Comment »

Death by SGC

Posted by kinasepro on November 30, 2007

SGC’s got another pre-release, this one’s a ligated DAPK3A; soon to be: 3BHY

striking an impressive pose @ 1.24Å

CN2C3=C([C@@H](C#N)C4(CCN(C)CC4)NC3=O)C1=CC=C(Cl)C(Cl)=C12

died and gone to pdb heaven

Posted in PDB, SGC | 2 Comments »