KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Lck’ Category

CH——-Pi

Posted by kinasepro on October 23, 2008

Kissei’s done a little math on LCK ligands and suggests the stablization owes to those methyl’s.

BMCL

Cool, yah ,so, umm, like, thats why they gotta be flat.

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Posted in General Interest, Lck | 8 Comments »

Plethora ‘o’ PDB’s

Posted by kinasepro on October 14, 2008

GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP

SGX: Jak2 3E64, 3E63, 3E62, BMCL

Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma

reminds me of OSI-906 or vice versa

Astrazeneca: CDK2 BMCL: 2W05

Amgen: P38 J Med Chem; 3DT1

LCK: 2ZM4, 2ZM1

Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »

Amgen all TIE2d up?

Posted by kinasepro on March 12, 2007

They describe Tie2 and LCK assays in a number of new apps, but it wouldn’t surprise me to learn a handful of other kinases were running in fear at the site of these things.

CC1=CC=C(C(NC2CC2)=O)C=C1C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3

app is US20070054916

They’ve also got a C-Met application this week with US20070054903:

O=C(C1=CC=CS1)NC2=CC=C3C=C(C4=CC=CC5=C(NCCCN(C)C)N=CC=C45)C=CC3=C2

Posted in Amgen, c-Met, Lck, TIE2 | 1 Comment »

Who’s in CA?

Posted by kinasepro on February 26, 2007

No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:

Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)

N#CC1=CN=C2C=C(OCCCN3CCN(C)CC3)C(OC)=CC2=C1NC4=CC(OC)=C(Cl)C=C4Cl

Roche talks P38: R1487

CN1C2=NC(NC3CCOCC3)=NC=C2C=C(OC4=C(F)C=C(F)C=C4)C1=O

And a former Abbot guy is talkinig LCK: A-770041

O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC

all great compounds and yadda yadda, just having a hard time seeing anything new here.

Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »