Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Lck’ Category


Posted by kinasepro on October 23, 2008

Kissei’s done a little math on LCK ligands and suggests the stablization owes to those methyl’s.


Cool, yah ,so, umm, like, thats why they gotta be flat.


Posted in General Interest, Lck | 8 Comments »

Plethora ‘o’ PDB’s

Posted by kinasepro on October 14, 2008

GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP

SGX: Jak2 3E64, 3E63, 3E62, BMCL

Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma

reminds me of OSI-906 or vice versa

Astrazeneca: CDK2 BMCL: 2W05

Amgen: P38 J Med Chem; 3DT1

LCK: 2ZM4, 2ZM1

Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »

Amgen all TIE2d up?

Posted by kinasepro on March 12, 2007

They describe Tie2 and LCK assays in a number of new apps, but it wouldn’t surprise me to learn a handful of other kinases were running in fear at the site of these things.


app is US20070054916

They’ve also got a C-Met application this week with US20070054903:



Posted in Amgen, c-Met, Lck, TIE2 | 1 Comment »

Who’s in CA?

Posted by kinasepro on February 26, 2007

No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:

Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)


Roche talks P38: R1487


And a former Abbot guy is talkinig LCK: A-770041


all great compounds and yadda yadda, just having a hard time seeing anything new here.


Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »