Archive for the ‘Flt3’ Category
Posted by kinasepro on March 26, 2009
Posted by kinasepro on December 7, 2007
Targegen’s got a press release:
Plans to initiate a multi-center clinical trial of TG101348, an internally discovered, oral, potent, and highly selective JAK2 inhibitor in January, 2008
A poster at ASH:
…Dual-Acting JAK2/FLT3 Small Molecule Kinase Inhibitor for the Treatment of AML
and some pyrimidines in WO/2007/053452:
Posted by kinasepro on November 14, 2007
- Ambit grabs 50M in a Series D. Their Lead is AC-220 a ph1 selective Flt3 compound. In WO/2007/109120?
aetiology and limited data in: WO/2005/048953
Posted by kinasepro on November 9, 2007
R-788 is Rigel’s SYK / Flt3 inhibiting prodrug of R-406, and despite a positive sounding press release on their Ph2 ITP study, the market is reacting negatively so far by knocking 20% off of the stock price.
the name suggests disodium.
Posted by kinasepro on June 26, 2007
Vegf, Flt3, Tie2, c-FMS, Pdgf, c-kit yadda yadda
Posted by kinasepro on June 1, 2007
Posted by kinasepro on May 28, 2007
Lestaurtinib / CEP-701 is currently in trials for a handful of indications and first appeared in WO/1988/07045 (US,4,923,986) via Kyowa Hakko Kogyo. The series was first described as a group of PKC inhibitors, but later came this ’98 press release: (emphasis mine)
CEP-701 is one of a series of specific receptor trk kinase inhibitor derived from the indolocarbazole K252a, which was originally synthesized by Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan
Posted by kinasepro on January 5, 2007
These are part of a Flt3 and/or TrkB series which JnJ has been putting a beat down on lately.
Posted by kinasepro on December 16, 2006
WTF J&J, Oxime-aldehydes? FLT3, TRKb, cKit inhibitors… Shinogi has some related EGF compounds: WO2006106721, and there’s a Biorg Med Chem Lett with the motif in CDK so its not unheard of. Quinazoline isosteres… Cool.
Update >> There’s a couple other relatives that make this a family of applications which all published last Thursday:
This looks like the primary series, and the aniline appears to dial in TRKB – albeit not all that dramatically: US20060281772
Hmm… is LG293 TRKb?