Kinase Chemistry – Just a year and a half behind the times.

Archive for July, 2009


Posted by kinasepro on July 31, 2009

Its a salt form of ENMD-981693…CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(CC4)C)=C2)=NN1


Posted in Aurora | 3 Comments »

AZ’s got PI3K

Posted by kinasepro on July 30, 2009


WO/2009/093972 reminds you of…

Posted in Astra, pi3k | 3 Comments »

Pi3k @ Bayer

Posted by kinasepro on July 25, 2009

This one hones in on the sulphonamides: (from the former site in CT)O=C(C1=CC=CN=C1)NC2=NC3=C(OC)C(OCCOCCNS(C)(=O)=O)=CC=C3C4=NCCN24

WO/2009/091550; They stuck morpholines out there previously: WO/2008/070150


Posted in Bayer, pi3k | 1 Comment »

Biogen Nominated…

Posted by kinasepro on July 14, 2009

… A RAF candidate & Sunesis got a milestone,

In August 2004 the companies entered into a collaboration to discover and develop small molecule cancer therapeutics targeting kinases, a family of cell signaling enzymes that play a major role in the progression of cancer. The research term of this collaboration ended in June of 2008. Sunesis retains an option to participate in the co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration.

Likely derived from WO/2009/006389WO/2009/006404



Posted in Biogen, RAF, Sunesis | 2 Comments »

What do…

Posted by kinasepro on July 10, 2009

…the Bee Gee’s and R406 have in common?

R-788 (a prodrug of R-406) has shown promise in a Ph2b trial. Partner Plz?

riglstill no BMCL


Posted in Rigel, SYK | 2 Comments »