WO/2009/093972 reminds you of…
Archive for the ‘Astra’ Category
Posted by kinasepro on June 2, 2009
Two allosteric inhibitors are better then one!
AZD-6244 is Array’s MEK inhibitor [ARRY-886] which failed a solo ph2 endpoint not too long ago.
MK-2206 is Merck’s ph1 AKT inhibitor
Posted by kinasepro on October 23, 2008
aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor II’ in the combination app WO/2008/125820:
Posted by kinasepro on October 11, 2008
Posted by kinasepro on October 2, 2008
Posted by kinasepro on September 25, 2008
Posted by kinasepro on September 4, 2008
+ XRPD on multiple salt forms of this EphB4 inhibitor:
Posted by kinasepro on August 10, 2007
WO/2007/089192 is a use app, and WO/2007/089191 is salt forms application of the pictured GSK3 inhibitor originally from WO/2003/08285. The YM-231146 / YM-359445 series bears similarity, albeit for Vegf.
Posted by kinasepro on July 2, 2007
Title’d app is from AstraZeneca and has ’bout 82 thiazoles said to hit c-Fms.
click for the guess Read the rest of this entry »