=CN(C2=NC(N3CCOCC3)=C4)C4=O)C](https://kinasepro.wordpress.com/wp-content/uploads/2009/07/az-pi3k-structure.jpg?w=220&h=227 "az-pi3k-structure")
WO/2009/093972 reminds you of…
Archive for the ‘Astra’ Category
MK n AZ
Posted by kinasepro on June 2, 2009
Two allosteric inhibitors are better then one!
AZD-6244 is Array’s MEK inhibitor [ARRY-886] which failed a solo ph2 endpoint not too long ago.
MK-2206 is Merck’s ph1 AKT inhibitor
Posted in Array, Astra, Merck & Co. | Leave a Comment »
ARRY-704 ?
Posted by kinasepro on October 23, 2008
aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor II’ in the combination app WO/2008/125820:
Posted in Array, Astra, MEK | 2 Comments »
Astra’s got IGF1R
Posted by kinasepro on October 2, 2008
Its not in the pipeline, but it is a candidate. WO/2008/117051 has xrpd, and lots of data.
![CC1=CC(NC2=NC(N3CCC[C@H]3C4=NOC(C5=NC=CC=N5)=C4)=NC(OC)=C2)=NN1](https://kinasepro.wordpress.com/wp-content/uploads/2008/10/astra-igf1r.jpg "astra-igf1r")
10x enough?
Posted in Astra, IGF | 1 Comment »
AZD-7762
Posted by kinasepro on September 25, 2008
It’s going ph1, it’s from WO/2005/066163, and it’s been described.
![O=C(C1=C(NC(N)=O)C=C(C2=CC=CC(F)=C2)S1)N[C@H]3CNCCC3](https://kinasepro.wordpress.com/wp-content/uploads/2008/09/azd77621.jpg "azd7762")
Somebody send it to Ambit. XL-844, PF-477736, IC-83 are the known competition.
Posted in Astra, Chk1 | Leave a Comment »
AZ’s Bis-Morpholine
Posted by kinasepro on September 4, 2008
Posted in Astra, EphB4 | Leave a Comment »
AZ’s GSK3 Indolinone
Posted by kinasepro on August 10, 2007
WO/2007/089192 is a use app, and WO/2007/089191 is salt forms application of the pictured GSK3 inhibitor originally from WO/2003/08285. The YM-231146 / YM-359445 series bears similarity, albeit for Vegf.
The PDB used for alignment is 1UV5, and you can also check out AZ’s publicized interest in selective GSK3 inhibition in an ’03 JBC and 1q5k.
Posted in Astra, biotech, GSK3 | 2 Comments »
WO/2007/071955
Posted by kinasepro on July 2, 2007
Title’d app is from AstraZeneca and has ’bout 82 thiazoles said to hit c-Fms.
click for the guess Read the rest of this entry »
Posted in Astra, c-fms | 2 Comments »
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