Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Merck’ Category


Posted by kinasepro on April 23, 2009

Merck‘s Ph1 allosteric AKT inhibitor:

NC1(CCC1)C(C=C2)=CC=C2C3=NC4=C(C=C3C5=CC=CC=C5)C(N6C=C4)=NNC6=OBinds to the Pleckstrin homology domain
Akt1 8 nM
Akt2 12 nM
Akt3 65 nM

thanks Ghost and Redferret for the structure

Posted in AKT, Merck | 6 Comments »