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Archive for the ‘Takeda’ Category

TAK-901

Posted by kinasepro on June 18, 2009

TAK-901 is Takeda’s ph1 Aurora B kinase inhibitor & US20090156557 suggests its:O=C(C1=C(C)C2=C(C(C3=CC=CC(S(=O)(CC)=O)=C3)=C1)C4=CC(C)=CN=C4N2)NC5CCN(C)CC5

previously…

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Posted in Aurora, Takeda | 7 Comments »

MLN-0415

Posted by kinasepro on May 2, 2009

Millenium’s beta-carboline’s aren’t new, but the structure of the Phase one IKK-B inhibitor hasn’t been released afaik.  Currrently in the Takeda pipeline via last years takeover.

ClC1=CC(NC([C@H]2N(CC(C)(OC2)C)CC(N3C[C@H](O[C@H](C3)C)C)=O)=O)=C(C4=C1)NC5=C4C=CN=C5WO/2009/054970

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Posted in IKK, Millenium, Takeda | Leave a Comment »

Takeda’s got PLK1

Posted by kinasepro on April 2, 2009

WO/2009/042806 & WO/2009/042711

FC1(F)CN(C2CCCC2)C(N=C3NC(C=CC(C(NC4CCN(CC4)C)=O)=C5)=C5OC)=C(C=N3)N(C)C1=O

process app.

Posted in Plk1, Takeda | 2 Comments »

MLN-518

Posted by kinasepro on April 1, 2009

aka Tandutinib is Takeda’s Ph2 FLT3, cKIT, PDGFR inhibitor Blood.

O=C(NC1=CC=C(C=C1)OC(C)C)N2CCN(CC2)C3=C4C=C(C(OCCCN5CCCCC5)=CC4=NC=N3)OC

Posted in Flt3, PDGFR, Takeda | Leave a Comment »

Takeda’s got…

Posted by kinasepro on September 24, 2008

a Jnk3 BMCL:

2ZDT and 2ZDU …reminds of 2R9S

Posted in Jnk, Takeda | Leave a Comment »

Takeda w/ more-a Aurora

Posted by kinasepro on April 23, 2007

Takeda has been looking at compounds similar to vx-680 for a while now, and the same group now has WO/2007/044779. The pretty colors give an idea whats going on, but frankly we all suck at drawing squishy things… for now your stuck with pymol!

CC1=CC2=C(NC3=C2C(C4=CC=CC(S(=O)(CC)=O)=C4)=CC(C(NCCN5CCCC5)=O)=C3C)N=C1

2BFY shows a sulfonamide down thereabout in Aurora-B.

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Takeda to BMS: pwned

Posted by kinasepro on January 6, 2007

So if your on the Aurora program at BMS you had to be a little disturbed when you saw US2006084650 with a priority date of: Oct 15, ’04 come out back in April ’06 as your earliest provisionals are from July 1 ’05. Who knows maybe there’s enough room in the sandbox for both. Takeda’s primary series appears to be the imidazopyrimidine anyways, but the pyrollo compounds are claimed and exemplified.

CC1=CC(NC2=NC(SC3=CC=C(NC(C4CC4)=O)C=C3)=CC5=NC(CN(C)C)=CN52)=NN1  CC1=CC(NC2=NC(SC3=CC=C(NC(C4CC4)=O)C=C3)=NN5C2=CC=C5)=NN1  CC1=CC(NC2=NC(SC3=CC=C(NC(C4CC4)=O)C=C3)=NC(N5CCN(C)CC5)=C2)=NN1

US20070004734; US20070004731

Posted in Aurora, BMS, Takeda | Leave a Comment »