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Archive for the ‘Array’ Category

MK n AZ

Posted by kinasepro on June 2, 2009

Two allosteric inhibitors are better then one!

AZD-6244 is Array’s MEK inhibitor [ARRY-886] which failed a solo ph2 endpoint not too long ago.

MK-2206 is Merck’s ph1 AKT inhibitor

Posted in Array, Astra, Merck & Co. | Leave a Comment »

ARRY-704 ?

Posted by kinasepro on October 23, 2008

aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor II’ in the combination app WO/2008/125820:O=C(C(C=C1C)=C(NC2=CC=C(I)C=C2F)N(C)C1=O)NOCCO

Posted in Array, Astra, MEK | 2 Comments »

WO/2008/124323

Posted by kinasepro on October 22, 2008

Array’s got Pim:

F[C@H]1CNCC[C@@H]1OC2=CC=CC(C2=N3)=CC=C3C4=CN=C5N4C=CC(OC6CCOCC6)=C5

Posted in Array, pim1 | Leave a Comment »

ARRY-797 goes to the dentist…

Posted by kinasepro on November 20, 2007

Promoted to ph2:

to evaluate the efficacy of ARRY-797 in the management of postoperative dental pain…

CC(F)(CN1C2=C(C=N1)C=C(C(C(N[C@](CCNC)(C(N)=O)CCC3CC3)=O)=C2)OC4=C(C=C(C=C4)F)F)C

still no structure disclosed afaik, but likely a cousin of the above.

Posted in Array, p38 | 5 Comments »

Array: Bag ‘o’ cash en route

Posted by kinasepro on September 25, 2007

40M up front:

…Array will grant Celgene an option to select drugs developed under the collaboration that are directed to two of four mutually selected discovery targets

Looks like unpartnerds include: KSP, P38, P38/tie2, Erbb1-2RAF, TLR’s, etc

Posted in Array, Celgene, Deals | Leave a Comment »

WO/2007/103308

Posted by kinasepro on September 19, 2007

It’s an Array / Genentech c-Met app:

CCN(CC3)C[C@H](F)[C@H]3NC1=NNC2=C1C(OC4=CC=C(N([H])C(C5=CC=NN(C6=CC=C(F)C=C6)C5=O)=O)C=C4F)=CC=N2

Posted in Array, c-Met, Genentech | 8 Comments »

ARRY-380: an Array ErbB2 IND

Posted by kinasepro on August 4, 2007

IND: in the books, Market: not impressed. If you’ve been paying attention you already noticed Array’s got ‘n’ ErbB series published 5/24: WO/2007/059257

 

CC1=CC(NC2=NC=NC3=CC=C(C4=CC=C(CNCCS(=O)(C)=O)O4)C=C32)=CC=C1OC5=CC6=NC=NN6C=C5

ARRY-380, a selective, orally-active ErbB-2 inhibitor, has shown efficacy and is well-tolerated in preclinical models of human cancer.

Posted in Array, EGF | 1 Comment »

B-Raf from A-rray

Posted by kinasepro on March 14, 2007

Wo/2007/027855 Matches their earlier Raf kinase application – this time with furanopyridines and some new tail pieces.

O\N=C(CC1)/C(C1=C2)=CC=C2NC3=C(C(NC4CCN(C)CC4)=O)OC5=C3C=CN=C5

Posted in Array, RAF | 1 Comment »

AZ’s got TrkA

Posted by kinasepro on February 22, 2007

I haven’t read it, but Cephalon’s got an Expert Opinion on the Array Biopharma / AstraZeneca’s Trk-A applications: WO06087538, WO06087530

OC[C@@H](C1=CC=C(F)C=C1)N2C=NC3=CC(Cl)=C(NC4=NNC(C5CC5)=C4)N=C32 C[C@@H](NC1=NC2=C(N=C([H])N2C3=NNC(C4CC4)=C3)C=N1)C5=CC=C(F)C=C5

In the series there’s also: WO/2006/082392

N#CC1=CC(F)=C(NC2=NNC(C3CC3)=C2)N=C1N[C@H](C4=NC=C(F)C=C4)C

Cephalon’s got a staurosporine analog CEP-701 that hits the kinome, err I mean Vegfr-2, FLT-3, Trk-A and JAK-2 in ph3 trials for AML.

Bonus Link: Multi-Targeted Therapy = nice site.

Posted in Array, Astra, Trk | Leave a Comment »

Better Chemistry = Better Drugs

Posted by kinasepro on December 29, 2006

Wull Duh? But in this case it’s a webcast on medchem from some mostly non-chemists: David Snitman, Paul Goddard, Arthur Sands, and Jim Mahoney of Array, ARYx, Lexicon, and Surface Logix respectively.

Read the rest of this entry »

Posted in Array, biotech, Lexicon, MEK | 5 Comments »