Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Array’ Category


Posted by kinasepro on June 2, 2009

Two allosteric inhibitors are better then one!

AZD-6244 is Array’s MEK inhibitor [ARRY-886] which failed a solo ph2 endpoint not too long ago.

MK-2206 is Merck’s ph1 AKT inhibitor

Posted in Array, Astra, Merck & Co. | Leave a Comment »

ARRY-704 ?

Posted by kinasepro on October 23, 2008

aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor II’ in the combination app WO/2008/125820:O=C(C(C=C1C)=C(NC2=CC=C(I)C=C2F)N(C)C1=O)NOCCO

Posted in Array, Astra, MEK | 2 Comments »


Posted by kinasepro on October 22, 2008

Array’s got Pim:


Posted in Array, pim1 | Leave a Comment »

ARRY-797 goes to the dentist…

Posted by kinasepro on November 20, 2007

Promoted to ph2:

to evaluate the efficacy of ARRY-797 in the management of postoperative dental pain…


still no structure disclosed afaik, but likely a cousin of the above.

Posted in Array, p38 | 5 Comments »

Array: Bag ‘o’ cash en route

Posted by kinasepro on September 25, 2007

40M up front:

…Array will grant Celgene an option to select drugs developed under the collaboration that are directed to two of four mutually selected discovery targets

Looks like unpartnerds include: KSP, P38, P38/tie2, Erbb1-2RAF, TLR’s, etc

Posted in Array, Celgene, Deals | Leave a Comment »


Posted by kinasepro on September 19, 2007

It’s an Array / Genentech c-Met app:


Posted in Array, c-Met, Genentech | 8 Comments »

ARRY-380: an Array ErbB2 IND

Posted by kinasepro on August 4, 2007

IND: in the books, Market: not impressed. If you’ve been paying attention you already noticed Array’s got ‘n’ ErbB series published 5/24: WO/2007/059257



ARRY-380, a selective, orally-active ErbB-2 inhibitor, has shown efficacy and is well-tolerated in preclinical models of human cancer.

Posted in Array, EGF | 1 Comment »

B-Raf from A-rray

Posted by kinasepro on March 14, 2007

Wo/2007/027855 Matches their earlier Raf kinase application – this time with furanopyridines and some new tail pieces.


Posted in Array, RAF | 1 Comment »

AZ’s got TrkA

Posted by kinasepro on February 22, 2007

I haven’t read it, but Cephalon’s got an Expert Opinion on the Array Biopharma / AstraZeneca’s Trk-A applications: WO06087538, WO06087530

OC[C@@H](C1=CC=C(F)C=C1)N2C=NC3=CC(Cl)=C(NC4=NNC(C5CC5)=C4)N=C32 C[C@@H](NC1=NC2=C(N=C([H])N2C3=NNC(C4CC4)=C3)C=N1)C5=CC=C(F)C=C5

In the series there’s also: WO/2006/082392


Cephalon’s got a staurosporine analog CEP-701 that hits the kinome, err I mean Vegfr-2, FLT-3, Trk-A and JAK-2 in ph3 trials for AML.

Bonus Link: Multi-Targeted Therapy = nice site.

Posted in Array, Astra, Trk | Leave a Comment »

Better Chemistry = Better Drugs

Posted by kinasepro on December 29, 2006

Wull Duh? But in this case it’s a webcast on medchem from some mostly non-chemists: David Snitman, Paul Goddard, Arthur Sands, and Jim Mahoney of Array, ARYx, Lexicon, and Surface Logix respectively.

Read the rest of this entry »

Posted in Array, biotech, Lexicon, MEK | 5 Comments »