KinasePro

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Archive for the ‘Pfizer’ Category

p38: Not dead?

Posted by kinasepro on August 13, 2009

Well.. maybe this compound will kill it: Polymorphic Forms / WO/2009/098612 & its from Pfizer no less –

pfizerp38

Part Axitinib, part Birb, Part SGX… All MW: 700

Thanks for the email PN.

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Posted in p38, Pfizer | 8 Comments »

PH-797804

Posted by kinasepro on June 9, 2009

In Ph2 for COPD & it’s an atropisomer…(biochem)

pha-797804

Who wants to guess if its R or S

Process App: 20080177077
Backup: 20080269264

Posted in p38, Pfizer | 6 Comments »

Toceranib

Posted by kinasepro on June 3, 2009

aka Palladia, PHA-291639, & SU11654 got its FDA Approval today! Well… In dogs at least:.  It’s for canine mast cell tumors.

O=C(NCCN1CCCC1)C2=C(NC(/C=C3C(NC4=C\3C=C(C=C4)F)=O)=C2C)C yeh, its the pyrrolidine version of Sutent & its the phosphate salt

Posted in Approved, Pfizer | 8 Comments »

PF-04217903

Posted by kinasepro on May 12, 2009

This one snuck past me… and into the clinic.  Currently its Ph1 via: WO/2007/132308

OCCN(N=C1)C=C1C2=CN=C(N=NN3CC4=CC=C(N=CC=C5)C5=C4)C3=N2

this and PF-2341066 both still in the pipeline.

note also WO/2007/138472

Posted in c-Met, Pfizer | 1 Comment »

R-343

Posted by kinasepro on March 24, 2009

Structure’s a guess from process app: WO/2009/031011

FC(C=N1)=C(NC2=CC3=C(OC(F)(C(N3)=O)F)C=C2)N=C1NC4=CC(OCC(NC)=O)=CC=C4.OC5=C(C(O)=O)C=CC6=CC=CC=C65

Posted in Pfizer, Rigel, SYK | 2 Comments »

US20080255162

Posted by kinasepro on October 22, 2008

Pfizer’s got PI3K:

O=C(C1=CC(NC2=NC(C)=C(C=CC(N3C4CCCCC4)=O)C3=N2)=CN1C)O

previously:

Posted in Pfizer, pi3k | Leave a Comment »

PF-3814735

Posted by kinasepro on September 5, 2008

It’s Pfizer’s Ph1 Aurora inhibitor:

O=C(N1[C@H]2C3=CC=C(C=C3[C@@H]1CC2)NC4=NC(NC5CCC5)=C(C=N4)C(F)(F)F)CNC(C)=O

Posted in Aurora, Pfizer | Leave a Comment »

R-343

Posted by kinasepro on December 7, 2007

Rigel gets 5M & some good news from Pfizer:

Pfizer (NYSE: PFE), has begun a Phase 1 clinical trial of an inhaled formulation of Rigel’s small molecule syk kinase inhibitor, R343, for the treatment of allergic asthma

Posted in Pfizer, Rigel, SYK | 2 Comments »

Pfizer’s Jnk

Posted by kinasepro on November 15, 2007

SD’s got a series of Jnk1 inhibitors in WO/2007/125405:

COC1=CC=C(CC(NC2=NC=C(C=CC(C4=CN(C)N=C4)=C3)C3=C2)=O)C=C1

First half of the compounds look about like that one, and Jnk1 data is given…
Second half appear discretely in the claims and look more like Jnk3 inhibitors to me.

Posted in biotech, Jnk, Pfizer | 3 Comments »

PF-477736

Posted by kinasepro on October 12, 2007

PF-477736 is Pfizers phase 1 Chk1 inhibitor being given in combination with Gemcitabine. They haven’t confirmed the structure yet, but…

N[C@H](C5CCCCC5)C(NC4=CC1=C(C3=C4)C(C=NNC3=O)=C(C2=CN(N=C2)C)N1)=O

It just so happens that 2007/113671 covers the above Chk1 inhibitor in combination with chemotherapy.   It may be the wrong structure, but till proven thus, it’s on the list.  Click for selectivity. Read the rest of this entry »

Posted in Chk1, Pfizer | 7 Comments »