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Archive for the ‘FAK’ Category

Eck’s Got FAK

Posted by kinasepro on September 9, 2008

2JKQ, 2JKK, 2JKO, 2JKM,

Neat helix, & 2JKK is NVP TAE-226 but 2JKM (non-helix) is the closest thing to anything FAK in the clinic: PF-562271

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PF-562,271

Posted by kinasepro on June 7, 2007

>> update >> the compound’s in Ph1, and while they haven’t released the structure, below is my guess.

WO/2007/063384 is a ‘salts and solvates’ app of the pictured compound. It’s a FAK inhibitor, which you’ll likely hear about from Gordon.

CS(=O)(N(C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)C)=O

Discovery application WO/2004/056807.

Posted in FAK, Pfizer | 3 Comments »