Eck’s Got FAK

2JKQ, 2JKK, 2JKO, 2JKM,

Neat helix, & 2JKK is NVP TAE-226 but 2JKM (non-helix) is the closest thing to anything FAK in the clinic: PF-562271

PF-562,271

>> update >> the compound’s in Ph1, and while they haven’t released the structure, below is my guess.

WO/2007/063384 is a ‘salts and solvates’ app of the pictured compound. It’s a FAK inhibitor, which you’ll likely hear about from Gordon.

Discovery application WO/2004/056807.