=CN(C2=NC(N3CCOCC3)=C4)C4=O)C](https://kinasepro.wordpress.com/wp-content/uploads/2009/07/az-pi3k-structure.jpg?w=220&h=227 "az-pi3k-structure")
WO/2009/093972 reminds you of…
Archive for the ‘pi3k’ Category
Pi3k @ Bayer
Posted by kinasepro on July 25, 2009
This one hones in on the sulphonamides: (from the former site in CT)
WO/2009/091550; They stuck morpholines out there previously: WO/2008/070150
Posted in Bayer, pi3k | 1 Comment »
Best place to hide a PI3K review?
Posted by kinasepro on January 7, 2009
Somewhere like Biochimica et Biophysica Acta sure would do the trick.
You could also try and bury one somewhere over here or there too…
The BPA one’s good! Go check it out, thanks VC for the tip.
>> And another one >> Mol Cancer Ther now in on the act.
Posted in pi3k | 1 Comment »
WO/2008/124161
Posted by kinasepro on October 22, 2008
Exel’s got Pi3K-a in combination: Reminds one of the XL-147 combo study.
![COC1=CC2=C(NC3=CC=C(Cl)C(Cl)=C3F)N=CN=C2C=C1OCC(C4)C[C@]5([H])[C@@]4([H])CN(C)C5](https://kinasepro.wordpress.com/wp-content/uploads/2008/10/xl2.jpg "xl2")
So thats XL-647 ? I hadn’t heard.
Posted in EGF, Exelixis, pi3k | Leave a Comment »
Plethora ‘o’ PDB’s
Posted by kinasepro on October 14, 2008
GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP
SGX: Jak2 3E64, 3E63, 3E62, BMCL
Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma
reminds me of OSI-906 or vice versa
Amgen: P38 J Med Chem; 3DT1
Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »
A new PI3K PDB
Posted by kinasepro on September 2, 2008
Posted in biotech, PDB, pi3k | Leave a Comment »
XL-765
Posted by kinasepro on April 25, 2007
mTOR / Pi3k inhibitor IND application reported today. XL-147 is their other one, and three pi3k applications published last Thursday. WO/2007/044698, WO/2007/044729, WO/2007/044813
Till Nature disables hotlinking: here’s who’s got what from here.
Posted in Exelixis, pi3k | 2 Comments »
PX-866
Posted by kinasepro on April 17, 2007
PX-866 is a Wortmannin analog that came to Biomira as part of the Prolx deal.
![O=C1/C(C([C@]2(C)[C@@H](COC)O1)=C(O)C(C3=C2[C@H](OC(C)=O)C[C@@]4(C)[C@@]3([H])CCC4=O)=O)=C/N(CC=C)CC=C](https://i0.wp.com/img264.imageshack.us/img264/6248/px688tj0.jpg)
You synthetic junkies should recognize at least one of the names on the patent app. Appears to be a simple improvement to the michael acceptor.
1E7U shows the natural product covalently bound to Pi3k
=O)C[C@]45C)=C([C@@]5([H])CCC4=O)C3=O)(C)[C@@H](COC)O1](https://i0.wp.com/img172.imageshack.us/img172/3782/wortua6.jpg)
Posted in biotech, pi3k | Leave a Comment »
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