Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Phase III’ Category


Posted by kinasepro on April 3, 2009

aka: Masivet, Kinavet & AB-1010 quietly joined the Phase iii club when it went Ph3 back in December.



Posted in c-Kit, gleevec, PDGFR, Phase III | 3 Comments »


Posted by kinasepro on September 7, 2007

BI’s irreversible ErbB inhibitor to join the Ph3 club.


>> update they’ve named it Tovok

Posted in BI, EGF, Phase III | 4 Comments »


Posted by kinasepro on July 18, 2007

Pfizer’s Jak3 inhibitor CP-690,550 was described earlier listed as Ph ii-iii. For some reason that was changed, and all of its furthest advanced trials are Phase 2.

Posted in JAK, Phase III | 1 Comment »

I don’t know’s on third

Posted by kinasepro on June 19, 2007

Because? oh he’s centerfield…

So TM asked for it, and while most of these are scatterred about the site… It’s not such a bad idea to have all the not-yet-approved kinase inhibitors currently active in US phase three clinical trials here in one place:

In a maybe-not-so-chronoligical order: Arxxant, Enzastaurin, Recentin, Zactima, Axitinib, Motesanib, CP-690,550, Pazopanib, and Tasigna.

Missing any?

Posted in Phase III | 7 Comments »


Posted by kinasepro on June 19, 2007

aka nilotinib, AMN-107 is a Novartis’ follow-on to Gleevec.


wiki; clinic; WO/2002/022597

Posted in c-Kit, gleevec, Novartis, Phase III | Leave a Comment »


Posted by kinasepro on June 19, 2007

aka GW-786034 is GSK’s ‘pan Vegfr’ inhibitor:


salt: hydrochloride
some chemistry here.
clinic: ph iii: RCC, WO/2002/05911

Posted in GSK, Phase III, VEGF | Leave a Comment »


Posted by kinasepro on June 19, 2007

Motesanib diphosphate, AMG-706 hits: Vegfr1,2,3, c-kit, Pdgfr-b, and Ret


Salt: bisphosphonate
Clinic Ph iii: NSCLC
Cancer Res.; WO/2002/066470

Posted in Amgen, c-Kit, PDGFR, Phase III, VEGF | Leave a Comment »


Posted by kinasepro on June 19, 2007

aka AG-013736 is a Pfizer Vegf / c-FMS compound via Agouron.


Salt: Tosylate?
Clinic Ph iii: Pancreatic Cancer
WO/2001/002369; process app; ‘06 Asco,

Posted in c-fms, Pfizer, Phase III, VEGF | Leave a Comment »


Posted by kinasepro on June 19, 2007

aka vandetanib, ZD-6474 is Astra’s Vegf / EGF doublet inhbitor.


wiki, clinic, WO/2001/032651

Posted in Astra, EGF, Phase III, VEGF | 1 Comment »


Posted by kinasepro on June 19, 2007

aka cediranib, AZD-2171 is Astra’s Vegfr-1 & 2 inihbitor.


wiki; Clinic: a, b, c

Posted in Astra, Phase III, VEGF | Leave a Comment »