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Archive for the ‘IRAK’ Category

Amgen ‘n’ IRAK-4

Posted by kinasepro on February 20, 2007

Irak-4? Yah I never heard of it either, but the IRAKs appear to be immunology targets for which Amgen is way out in front. They’ve got a nice paper in Structure, a Biorg. Med. Chem. Lett., and 2 PDB’s: 2NRU, 2NRY.

At first look I was mesmerized by the tyrosine gatekeeper but a second glance on looking over the recent CIP: US20070037803 shows something interesting.

O=C(C1=CC(C(F)(F)F)=CC=C1)\N=C2N([C@@H]3CC[C@@H](O)CC3)C4=CC=C(OCCN5CCOCC5)C=C4N/2

they suggest as much in the BMCL. Read the rest of this entry »

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PDB Update

Posted by kinasepro on December 12, 2006

The highlight is GSK’s SB-590885 bound to B-Raf: 2FB8 (They describe the oxime as a phenol isostere)

O\N=C1CCC2=C/1C=CC(C(N=C(C3=CC=C(OCCN(C)C)C=C3)N4)=C4C5=CC=NC=C5)=C2

Also, Amgen released the structurally interesting IRAK-4 bound to staurosporine (2NRY), and a benzimidazole inhibitor (2NRU). The Bioorg Med Chem Lett came out in March and the Xray is featured in this Structure paper.

CC(C)(C)C(OC1=CC=C2C(N=C(NC(C3=CC=CC([N+]([O-])=O)=C3)=O)N2CCCO)=C1)=O

The tyrosine gatekeeper is certainly different

Looks like there’s an indolinone lodged in today’s update as well. 2JAV replaces 2CL1, dunno why, probably some sort of refinement. NEK2 ne1?

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