Archive for the ‘JAK’ Category
Posted by kinasepro on May 4, 2009
Posted by kinasepro on March 28, 2009
Posted by kinasepro on March 18, 2009
Posted by kinasepro on February 10, 2009
Thanks Cytopia & no I didn’t forget 3EYH
Posted by kinasepro on October 14, 2008
reminds me of OSI-906 or vice versa
Posted by kinasepro on October 11, 2008
Posted by kinasepro on December 7, 2007
Targegen’s got a press release:
Plans to initiate a multi-center clinical trial of TG101348, an internally discovered, oral, potent, and highly selective JAK2 inhibitor in January, 2008
A poster at ASH:
…Dual-Acting JAK2/FLT3 Small Molecule Kinase Inhibitor for the Treatment of AML
and some pyrimidines in WO/2007/053452:
Posted by kinasepro on August 14, 2007
27 Authors, 586 pages, a whole bunch of examples, and 20 MB of Jak-2 goodness.
Seems likely that XL-019 came out of this series.
Posted by kinasepro on August 9, 2007
The news today is that LS-104 is in Ph1 and now owned by Aegera from Lymphosign who in turn licsensed it from HSC. Their portfolio of patent applications suggests the compound is likely a tyrphostin derivative.
LS104 is a novel small molecule tyrosine kinase inhibitor of therapeutically significant kinases including Jak2 and Bcr-Abl…In contrast to marketed kinase inhibitor drugs, LS104 inhibits its targets in a non-ATP-competitive manner
I don’ t know about you but I needed a history lesson to get a handle on these…