pan-Jak:
Archive for the ‘JAK’ Category
Merck’s got Azaindoles
Posted by kinasepro on May 4, 2009
Posted in JAK, Merck & Co., PDK1 | Leave a Comment »
INCB018424
Posted by kinasepro on March 28, 2009
Incyte’s Ph2 Jak 1, 2 inhibitor: Org Lett; see also: WO/2008/157208
Keeping pace with CP-690550
Posted in JAK | 9 Comments »
AT-9283
Posted by kinasepro on March 18, 2009
Posted in Astex, Aurora, bcr abl, JAK | Leave a Comment »
CP-690,550
Posted by kinasepro on February 10, 2009
CP-690,550 is Pfizer’s Ph3 Jak inhibitor. J Mol Biol. JAK2: 3FUP & JAK1?: 3EYG
Thanks Cytopia & no I didn’t forget 3EYH
Posted in JAK, PDB | 3 Comments »
Plethora ‘o’ PDB’s
Posted by kinasepro on October 14, 2008
GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP
SGX: Jak2 3E64, 3E63, 3E62, BMCL
Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma
reminds me of OSI-906 or vice versa
Amgen: P38 J Med Chem; 3DT1
Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »
Palau ‘n’ Jak3
Posted by kinasepro on October 11, 2008
Palau’s got Jak3: WO/2008/119792, purines for Jak3: WO/2008/090181 too. From the sound of their pipeline DP1’s in there somewhere.
Posted in biotech, JAK | 1 Comment »
TG-101348
Posted by kinasepro on December 7, 2007
Targegen’s got a press release:
Plans to initiate a multi-center clinical trial of TG101348, an internally discovered, oral, potent, and highly selective JAK2 inhibitor in January, 2008
A poster at ASH:
…Dual-Acting JAK2/FLT3 Small Molecule Kinase Inhibitor for the Treatment of AML
and some pyrimidines in WO/2007/053452:
Posted in biotech, clinical, Flt3, JAK | Leave a Comment »
WO/2007/089768
Posted by kinasepro on August 14, 2007
27 Authors, 586 pages, a whole bunch of examples, and 20 MB of Jak-2 goodness.
Seems likely that XL-019 came out of this series.
Posted in Exelixis, JAK | 1 Comment »
LS-104
Posted by kinasepro on August 9, 2007
The news today is that LS-104 is in Ph1 and now owned by Aegera from Lymphosign who in turn licsensed it from HSC. Their portfolio of patent applications suggests the compound is likely a tyrphostin derivative.
LS104 is a novel small molecule tyrosine kinase inhibitor of therapeutically significant kinases including Jak2 and Bcr-Abl…In contrast to marketed kinase inhibitor drugs, LS104 inhibits its targets in a non-ATP-competitive manner
I don’ t know about you but I needed a history lesson to get a handle on these…
Posted in bcr abl, biotech, JAK | 2 Comments »
Correction
Posted by kinasepro on July 18, 2007
Pfizer’s Jak3 inhibitor CP-690,550 was described earlier listed as Ph ii-iii. For some reason that was changed, and all of its furthest advanced trials are Phase 2.
Posted in JAK, Phase III | 1 Comment »