Archive for the ‘Plexxikon’ Category
Posted by kinasepro on September 3, 2008
Plexxikon’s Ph1 in healthy volunteers underway with plans for and pain and PKD. They’re not advertising the target, but my guess is c-fms. We’ve been following their earlier cFms / cKkit double-stuff, and its likely they found a group to tune out the Kit, maybe something like: WO/2008/080015
still no partner…
Posted by kinasepro on February 10, 2007
Some of Plexxicon’s latest cKit / cFms stuff has published, and surprise-surprise its got their ‘scaffold’. The choice of where to tag on amines suggests the following motif:
Posted by kinasepro on January 8, 2007
So you know that kinase your working on. Yah, yah that one. Turns out that Plexxikon has compounds that inhibit it too. No, really. Between their two most recent applications to publish: WO/2007/002325, and WO/2007/002433 they claim <10 uM inhibition on no less then 36 kinases (+ n isoforms) with 22 authors. It’s an impressive body of matter, if pyrrolopyridines are your thing, and 1200+ pages of patent apps don’t scare you, check it out.