KinasePro

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Archive for the ‘Sunesis’ Category

Biogen Nominated…

Posted by kinasepro on July 14, 2009

… A RAF candidate & Sunesis got a milestone,

In August 2004 the companies entered into a collaboration to discover and develop small molecule cancer therapeutics targeting kinases, a family of cell signaling enzymes that play a major role in the progression of cancer. The research term of this collaboration ended in June of 2008. Sunesis retains an option to participate in the co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration.

Likely derived from WO/2009/006389 &  WO/2009/006404

O=C(N1)CN(C)CC2=C1N=CN=C2C(N[C@H](C)C3=NC=C(C(NC4=CC(C(F)(F)F)=C(Cl)C=C4)=O)S3)=O

Posted in Biogen, RAF, Sunesis | 2 Comments »

SNS-314

Posted by kinasepro on May 12, 2009

Sunesis’ Ph1 Aurora inhibitor:

O=C(NC1=NC=C(CCNC2=C3C(C=CS3)=NC=N2)S1)NC4=CC=CC(Cl)=C4
Related PDB’s: 3D15,3D14,3D2I,3DJ7
Amgen’s related pyrimidine: 3EFW

Read the rest of this entry »

Posted in Aurora, Sunesis | 1 Comment »

SNS-032

Posted by kinasepro on March 6, 2007

‘nother Phase1 underway CDK2,7,9 formerly BMS-387032 for

patients with advanced B-cell malignancies

O=C(C1CCNCC1)NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2

press release and an ‘old’ J Med Chem.

Posted in CDK2, Sunesis | Leave a Comment »

SNS-314

Posted by kinasepro on March 3, 2007

Sunesis submitted an IND application for SNS-314 the other day. It’s an Aurora inhibitor, likely coming out of: WO/2007/013964 / US20070027166

O=C(NC1=CC(Cl)=CC=C1)NC(S2)=NC=C2CCNC3=C4C(C=NN4CCN5C[C@@H](O)CC5)=NC=N3

update:: poster here

the poster indicates 314 is <450 mw

Posted in Aurora, Sunesis | Leave a Comment »