KinasePro

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Archive for the ‘Aurora’ Category

ENMD-2076

Posted by kinasepro on July 31, 2009

Its a salt form of ENMD-981693…CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(CC4)C)=C2)=NN1

Posted in Aurora | 3 Comments »

AMG-900

Posted by kinasepro on June 28, 2009

It’s a Ph1 Aurora A/B/C inhibitor for ‘solid tumors’.  Seems likely to be a member of one of the phthalazine series’ WO/2008/124083, WO/2008/057280, WO/2007/100646, or WO/2007/087276.

COC1=CC2=NC=CC(OC3=CC=C(NC(N=N4)=C5C=CC=CC5=C4C6=CC=CC=C6)C=C3)=C2C=C1OCpreviously…

Posted in Amgen, Aurora | 2 Comments »

TAK-901

Posted by kinasepro on June 18, 2009

TAK-901 is Takeda’s ph1 Aurora B kinase inhibitor & US20090156557 suggests its:O=C(C1=C(C)C2=C(C(C3=CC=CC(S(=O)(CC)=O)=C3)=C1)C4=CC(C)=CN=C4N2)NC5CCN(C)CC5

previously…

Posted in Aurora, Takeda | 7 Comments »

SNS-314

Posted by kinasepro on May 12, 2009

Sunesis’ Ph1 Aurora inhibitor:

O=C(NC1=NC=C(CCNC2=C3C(C=CS3)=NC=N2)S1)NC4=CC=CC(Cl)=C4
Related PDB’s: 3D15,3D14,3D2I,3DJ7
Amgen’s related pyrimidine: 3EFW

Read the rest of this entry »

Posted in Aurora, Sunesis | 1 Comment »

AT-9283

Posted by kinasepro on March 18, 2009

Astex’s unpartnered JAK/Aur/Abl Ph1b nibO=C(NC1=CNN=C1C2=NC3=C(N2)C=CC(CN4CCOCC4)=C3)NC5CC5

poster; clinic; PDB: 2W1G & 2W1I

Posted in Astex, Aurora, bcr abl, JAK | Leave a Comment »

PDB Update

Posted by kinasepro on October 29, 2008

Aurora A + 680: 3E5A; Protien Sci

Aurora B: 2VGO; Mol Cell Ther

SRC: 3EL7 & 3EL8; Chem Biol;

EPHB4: 2VWX; 2VWY; 2VX0, 2VX1

Posted in Aurora, EphB4, PDB, SRC | 2 Comments »

PF-3814735

Posted by kinasepro on September 5, 2008

It’s Pfizer’s Ph1 Aurora inhibitor:

O=C(N1[C@H]2C3=CC=C(C=C3[C@@H]1CC2)NC4=NC(NC5CCC5)=C(C=N4)C(F)(F)F)CNC(C)=O

Posted in Aurora, Pfizer | Leave a Comment »

VX-680, VX-667: Done

Posted by kinasepro on November 21, 2007

VX-680 halted as:

one patient experienced QTc prolongation.

O=C(C3CC3)NC(C=C4)=CC=C4SC1=NC(N2CCN(C)CC2)=CC(NC5=NNC(C)=C5)=N1

and the follow-on, VX-667:

Failed to meet pharmacokinetic objectives in a Phase 1 trial

Posted in Aurora, Merck & Co., Vertex | 15 Comments »

News of the day

Posted by kinasepro on November 14, 2007

 O=C(N([H])C2=CC=C(C3=CN4C(SC5=CC(N6CCN(C)CC6)=CC=C45)=N3)C=C2)N([H])C1=NOC(C(C)(C)C)=C1

aetiology and limited data in: WO/2005/048953

Posted in Ambit, Aurora, Deals, Flt3, Rigel | 16 Comments »

Banyu’s …

Posted by kinasepro on November 12, 2007

… got more Aurora A compounds in WO/07/126126:

InChI=1/C25H27ClFN7O2/c1-14-7-22(31-30-14)29-21-9-15(24(35)32(2)3)8-16(28-21)11-33-12-18-10-17(33)13-34(18)25(36)19-5-4-6-20(26)23(19)27/h4-9,17-18H,10-13H2,1-3H3,(H2,28,29,30,31)/t17-,18-/m0/s1

drawn with Depthfirst‘s Inchimatic.

Posted in Aurora, Banyu | 1 Comment »