KinasePro

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Archive for the ‘Abbott’ Category

ABT-869

Posted by kinasepro on March 18, 2009

Vegf, Etc – Boring & Healthy…Tons of Ph2s in HCC but is it better then Sorafenib?

O=C(NC1=CC=C(C=C1)C2=CC=CC3=C2C(N)=NN3)NC4=CC(C)=CC=C4Fno news is good news?

previously

Posted in Abbott, Genentech, TIE2, VEGF | Leave a Comment »

ABT-869

Posted by kinasepro on June 26, 2007

Phase 2 on the doorstep, Genentech and Abbott just announced a collaboration to include development of the compound w/ backups. No terms disclosed…

O=C(NC1=CC=C(C=C1)C2=CC=CC3=C2C(N)=NN3)NC4=CC(C)=CC=C4F

Vegf, Flt3, Tie2, c-FMS, Pdgf, c-kit yadda yadda

j med chem, blood, molec cancer ther., WO/2004/113304

Posted in Abbott, c-fms, Flt3, Genentech, PDGFR, TIE2, VEGF | Leave a Comment »

A-[CEP-701]

Posted by kinasepro on June 25, 2007

So, what’s Abbott doing making solid forms of Lestaurtinib?

WO/2007/070444, US20070135628, US20070135401

Oh, and CC pointed out that CEP-701 / lestaurtinib is claimed to be in Ph3 trials for AML, so add that one to the list, I guess. I can’t find the trial in the US or EU databases, so may be in Asia?

Posted in Abbott, Cephalon | Leave a Comment »

PDB Update

Posted by kinasepro on June 5, 2007

Some kind of coincidence that this week’s update are all indazoles? Hmm…

2UZT Abbott; AKT;
2UZU A-443654
2UZV
2UZW

The real action with these is what’s going on with the indole though.

Read the rest of this entry »

Posted in Abbott, AKT, PDB | Leave a Comment »

PDB Update

Posted by kinasepro on April 17, 2007

Abbott’s got an anilinopyrimidine bound to Jnk1 with 2No3; BMCL. Their other JNK1 structure is 2g01

Posted in Abbott, Jnk, PDB | Leave a Comment »

PDB Update

Posted by kinasepro on March 27, 2007

2GHG Abbott – Chk1 with A431994 (Akt inhibitor) BMCL ’06, 3424

O=C1NC2=C(C=C(C3=CC(OC[C@@H](N)CC4=CNC5=C4C=CC=C5)=CN=C3)C=C2)/C1=C/C6=CC=CN6

I haven’t read the article yet, but to my eye the PDB suggests a ligand conformation responsible for some off target activity. Abbott’s indole-aminoethoxides in last weeks update (2OH0, 2OJF) seem to be the more typical (potent?) conformation.

Posted in Abbott, PDB | 2 Comments »

Abbott: not done with P38 either

Posted by kinasepro on March 14, 2007

WO/2007/028051 is another p38 application suggesting that Abbott isn’t throwing in the towel just yet

CC(C)OC1=NC=CN2C1=NC(C3=CC=C(F)C=C3)=C2C4=CC=NC(NCC(C)(C)CO)=N4

Posted in Abbott, p38 | 3 Comments »

Who’s in CA?

Posted by kinasepro on February 26, 2007

No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:

Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)

N#CC1=CN=C2C=C(OCCCN3CCN(C)CC3)C(OC)=CC2=C1NC4=CC(OC)=C(Cl)C=C4Cl

Roche talks P38: R1487

CN1C2=NC(NC3CCOCC3)=NC=C2C=C(OC4=C(F)C=C(F)C=C4)C1=O

And a former Abbot guy is talkinig LCK: A-770041

O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC

all great compounds and yadda yadda, just having a hard time seeing anything new here.

Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »

US20060270663

Posted by kinasepro on December 2, 2006

Hi Abbott, VEGF / TIE2 inhibitor, eh? Check 1ywn for similar.

nuff said.

Posted in Abbott, TIE2, VEGF | Leave a Comment »