Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Abbott’ Category


Posted by kinasepro on March 18, 2009

Vegf, Etc – Boring & Healthy…Tons of Ph2s in HCC but is it better then Sorafenib?

O=C(NC1=CC=C(C=C1)C2=CC=CC3=C2C(N)=NN3)NC4=CC(C)=CC=C4Fno news is good news?



Posted in Abbott, Genentech, TIE2, VEGF | Leave a Comment »


Posted by kinasepro on June 26, 2007

Phase 2 on the doorstep, Genentech and Abbott just announced a collaboration to include development of the compound w/ backups. No terms disclosed…


Vegf, Flt3, Tie2, c-FMS, Pdgf, c-kit yadda yadda

j med chem, blood, molec cancer ther., WO/2004/113304

Posted in Abbott, c-fms, Flt3, Genentech, PDGFR, TIE2, VEGF | Leave a Comment »


Posted by kinasepro on June 25, 2007

So, what’s Abbott doing making solid forms of Lestaurtinib?

WO/2007/070444, US20070135628, US20070135401

Oh, and CC pointed out that CEP-701 / lestaurtinib is claimed to be in Ph3 trials for AML, so add that one to the list, I guess. I can’t find the trial in the US or EU databases, so may be in Asia?


Posted in Abbott, Cephalon | Leave a Comment »

PDB Update

Posted by kinasepro on June 5, 2007

Some kind of coincidence that this week’s update are all indazoles? Hmm…

2UZT Abbott; AKT;
2UZU A-443654

The real action with these is what’s going on with the indole though.

Read the rest of this entry »


Posted in Abbott, AKT, PDB | Leave a Comment »

PDB Update

Posted by kinasepro on April 17, 2007

Abbott’s got an anilinopyrimidine bound to Jnk1 with 2No3; BMCL. Their other JNK1 structure is 2g01


Posted in Abbott, Jnk, PDB | Leave a Comment »

PDB Update

Posted by kinasepro on March 27, 2007

2GHG Abbott – Chk1 with A431994 (Akt inhibitor) BMCL ’06, 3424


I haven’t read the article yet, but to my eye the PDB suggests a ligand conformation responsible for some off target activity. Abbott’s indole-aminoethoxides in last weeks update (2OH0, 2OJF) seem to be the more typical (potent?) conformation.


Posted in Abbott, PDB | 2 Comments »

Abbott: not done with P38 either

Posted by kinasepro on March 14, 2007

WO/2007/028051 is another p38 application suggesting that Abbott isn’t throwing in the towel just yet



Posted in Abbott, p38 | 3 Comments »

Who’s in CA?

Posted by kinasepro on February 26, 2007

No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:

Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)


Roche talks P38: R1487


And a former Abbot guy is talkinig LCK: A-770041


all great compounds and yadda yadda, just having a hard time seeing anything new here.


Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »


Posted by kinasepro on December 2, 2006

Hi Abbott, VEGF / TIE2 inhibitor, eh? Check 1ywn for similar.

nuff said.


Posted in Abbott, TIE2, VEGF | Leave a Comment »