Archive for the ‘Wyeth’ Category
Posted by kinasepro on October 23, 2008
Posted by kinasepro on September 23, 2007
Wyeth’s got some new RAF stuff with US20070219186:
data on p19
This one’s got me wondering…
Posted by kinasepro on February 26, 2007
Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)
Roche talks P38: R1487
And a former Abbot guy is talkinig LCK: A-770041
all great compounds and yadda yadda, just having a hard time seeing anything new here.
Posted by kinasepro on February 22, 2007
Posted by kinasepro on December 30, 2006
…Wyeth will pay Pharmacopeia $5 million initially, as much as $9 million of research funding over the next three years, and as much as $175 million for reaching certain goals with the JAK3 kinase inhibitor drug.
While it’s likely they have a few which haven’t published yet, WO/2006/108103 is the most recent PCOP Jak3 application.
>> update 1/25/07 >> US20070021443 Jak3 Pharmacopeia patent application
Posted by kinasepro on December 7, 2006
These are Wyeth’s EKB569 analogs which are covalent inhibitors of EGF.
There’s a cystine residue in proximity which adds 1,4 to the butenamide.
Posted by kinasepro on November 27, 2006
Hey Wyeth, so is TPL2 for real? I see people have been talking up Cot/TPL2/MAP3K8 as another tnf-α inhibiting kinase target, but it seems that nobody else (cept maybe Abbott) seems to have jumped on board yet.
Yes that is a chloride atom there hugging the hinge.
Bioorg Med Chem Lett 2006, 6067
Bioorg Med Chem Lett 2005, 5288
(unrelated Abbott tpl2 series: WO2005110410)
ps. Thanks T.S. for the tip that wipo search feature bears much to be loved.
Posted by kinasepro on November 4, 2006