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Archive for the ‘Wyeth’ Category

Wyeth’s IKK candidate

Posted by kinasepro on October 23, 2008

US20080262010: D-glucuronate
US20080262009: acetate
US20080262008: succinate

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Posted in IKK, Wyeth | Leave a Comment »

Raf… Weird…

Posted by kinasepro on September 23, 2007

Wyeth’s got some new RAF stuff with US20070219186:

O=C(NC2=CC=CC(C3=CC=NC4=C(C5=CC=C(CN6CCCC6)C=C5)C=NN34)=C2)C1=CC=CC(C(F)(F)F)=C1

data on p19

This one’s got me wondering…

Posted in RAF, Wyeth | 7 Comments »

Who’s in CA?

Posted by kinasepro on February 26, 2007

No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:

Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)

N#CC1=CN=C2C=C(OCCCN3CCN(C)CC3)C(OC)=CC2=C1NC4=CC(OC)=C(Cl)C=C4Cl

Roche talks P38: R1487

CN1C2=NC(NC3CCOCC3)=NC=C2C=C(OC4=C(F)C=C(F)C=C4)C1=O

And a former Abbot guy is talkinig LCK: A-770041

O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC

all great compounds and yadda yadda, just having a hard time seeing anything new here.

Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »

What’s this I hear?

Posted by kinasepro on February 22, 2007

Is that the sweet sound of Kinase-Blogging Whistling in the Wind? Why yes, yes indeed it is.  (link to the original KP entry)

Read the rest of this entry »

Posted in General Interest, Wyeth | 3 Comments »

Wyeth gets Jak’d up!

Posted by kinasepro on December 30, 2006

via Jak3 but of course – in an underanounced deal with Pharmacopeia:

…Wyeth will pay Pharmacopeia $5 million initially, as much as $9 million of research funding over the next three years, and as much as $175 million for reaching certain goals with the JAK3 kinase inhibitor drug.

While it’s likely they have a few which haven’t published yet, WO/2006/108103 is the most recent PCOP Jak3 application.

O=C1NC2=C(N=C(N3C4=CC(F)=CC=C4N=C3)N=C2)N1[C@H]5CCC(C6=C5C=CC=C6)=O

They’ve been at this stuff for a while – I reckon since WO/2001/047921 and have a recent Tet Lett on a related series. Check 2HK5 for a clue on how they bind.

>> update 1/25/07 >> US20070021443 Jak3 Pharmacopeia patent application

Posted in Deals, JAK, Pharmacopeia, Wyeth | 3 Comments »

US20060270670

Posted by kinasepro on December 7, 2006

These are Wyeth’s EKB569 analogs which are covalent inhibitors of EGF.
There’s a cystine residue in proximity which adds 1,4 to the butenamide.

 

CCOC1=C(NC(/C=C/CN(C)C)=O)C=C(C(NC2=CC(Cl)=C(OCC3=CC=CC=N3)C=C2)=C(C#N)C=N4)C4=C1

US20060270669 Process for making these sorts of things.
US20060270668 Other process for making these sorts of things.

Posted in EGF, Wyeth | 5 Comments »

TPL2 4 Real?

Posted by kinasepro on November 27, 2006

Hey Wyeth, so is TPL2 for real? I see people have been talking up Cot/TPL2/MAP3K8 as another tnf-α inhibiting kinase target, but it seems that nobody else (cept maybe Abbott) seems to have jumped on board yet.

Yes that is a chloride atom there hugging the hinge.

WO2006124692
WO2006124944

Bioorg Med Chem Lett 2006, 6067
Bioorg Med Chem Lett 2005, 5288
(unrelated Abbott tpl2 series: WO2005110410)

ps. Thanks T.S. for the tip that wipo search feature bears much to be loved.

Posted in tpl2, Wyeth | 3 Comments »

US20060247217

Posted by kinasepro on November 4, 2006

Not terribly new, but none-the-less entertaining. This is a divisional application of Wyeth’s 6,6,6 5,6,6 and 6,5,6 tricycles. They are SRC inhibitors, and there’s already a J. Med. Chem.

N#CC1=C(NC2=C(Cl)C=C(Cl)C(OC)=C2)C3=CC4=CC(OC)=C(OCCCN5CCOCC5)C=C4C=C3N=C1

Posted in SRC, Wyeth | Leave a Comment »