The 15M Pharmacopeia and Cephalon deal from a couple years ago was likely for compounds like these c-Met / Alk inhibitors:
yeh, its 1300 pages and I know they’re old, but I got some catching up to do…
Posted by kinasepro on August 21, 2008
The 15M Pharmacopeia and Cephalon deal from a couple years ago was likely for compounds like these c-Met / Alk inhibitors:
yeh, its 1300 pages and I know they’re old, but I got some catching up to do…
Posted in c-Met, Cephalon, Pharmacopeia | Leave a Comment »
Posted by kinasepro on August 20, 2008
The new ‘Perspective‘: Some useful information bracketed by useless commentary.
Affinity is not even a check-box on the road to an approved drug. What’s stopping 99.9% of real compounds coming from real programs isn’t potency. This makes a discussion of how many hydrogen bonds to the hinge are in approved drugs totally irrelevant.
Fact Check:
>> Ruboxistaurin is not an approved drug.
>> Fasudil is only approved in Japan.
>> And you forgot Tasigna
Posted in Cephalon, General Interest | Leave a Comment »
Posted by kinasepro on June 25, 2007
So, what’s Abbott doing making solid forms of Lestaurtinib?
WO/2007/070444, US20070135628, US20070135401
Oh, and CC pointed out that CEP-701 / lestaurtinib is claimed to be in Ph3 trials for AML, so add that one to the list, I guess. I can’t find the trial in the US or EU databases, so may be in Asia?
Posted in Abbott, Cephalon | Leave a Comment »
Posted by kinasepro on May 28, 2007
Lestaurtinib / CEP-701 is currently in trials for a handful of indications and first appeared in WO/1988/07045 (US,4,923,986) via Kyowa Hakko Kogyo. The series was first described as a group of PKC inhibitors, but later came this ’98 press release: (emphasis mine)
CEP-701 is one of a series of specific receptor trk kinase inhibitor derived from the indolocarbazole K252a, which was originally synthesized by Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan
Posted in c-Met, Cephalon, Flt3, JAK, Trk, VEGF | 3 Comments »