KinasePro

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Archive for the ‘SGC’ Category

3H9F

Posted by kinasepro on May 18, 2009

Normally…

3H9Fr

an A-loop doesn’t do that! (its new SGC prerelease of  a BI-PLK1-like inhibitor bound to TTK)

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ACVR1 + FKBP12

Posted by kinasepro on May 11, 2009

‘nother interesting SGC prerelease

sgc_2

The orange hat on top is FKB12, for which this kind of thing has been seen before w/ TGF-Beta, (1B6C) but this one’s ligated.  I suspect you could infer from this that inhibition of the active site wouldn’t preclude FKBP12 binding…

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SGC’s got…

Posted by kinasepro on October 17, 2008

Lots ‘o’ new stuff

DYRK1A: 2VX3


Haspin: 3E7V, 2VUW, 3DLZ

v-FES + SS: 3CD3,3CBL,3BKB; CELL

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Death by SGC

Posted by kinasepro on November 30, 2007

SGC’s got another pre-release, this one’s a ligated DAPK3A; soon to be: 3BHY

striking an impressive pose @ 1.24Å

CN2C3=C([C@@H](C#N)C4(CCN(C)CC4)NC3=O)C1=CC=C(Cl)C(Cl)=C12

died and gone to pdb heaven

Posted in PDB, SGC | 2 Comments »

SGC: PDB Update

Posted by kinasepro on November 29, 2007

Get y’r red-hot CAMK2B pre-release right here. 3BHH is a tetramer, with both an apo and a ligated forms represented.

Posted in Camk, PDB, SGC | 1 Comment »

SGC in DDT

Posted by kinasepro on May 30, 2007

The PDB is kind of light this week – but if the letters SGC mean anything to you then don’t miss this kinase review in Drug Discovery Today.

Posted in General Interest, SGC | Leave a Comment »