KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for August, 2009

p38: Not dead?

Posted by kinasepro on August 13, 2009

Well.. maybe this compound will kill it: Polymorphic Forms / WO/2009/098612 & its from Pfizer no less –

pfizerp38

Part Axitinib, part Birb, Part SGX… All MW: 700

Thanks for the email PN.

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Posted in p38, Pfizer | 8 Comments »

AT-131418

Posted by kinasepro on August 7, 2009

Astex has released data about their AKT program, including a PDB, but I have omitted that they appear to have dropped the strutcture of their candidate in WO/2008/110846

O[C@](CN)(C1=CC=C(Cl)C=C1)C(C=C2)=CC=C2C3=CNN=C3

Thanks, Ed.

Posted in AKT, Astex | 1 Comment »

BMS-817378

Posted by kinasepro on August 1, 2009

A comments to BMS-777607 suggest that this structure is the backup:

O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=CNC=C(C3=O)C4=CC=C(C=C4)F

WO/2009/094427

Posted in BMS, c-Met | 6 Comments »