KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘SGX’ Category

SGX-523

Posted by kinasepro on May 6, 2009

It’s SGX’s former Ph1 c-Met inhibitor & Derek‘s got a post on it.  Lilly released that the trial was halted due to a reversible acute renal failure in the 80 mg dose group brought on by a compound crystallizing in the kidney.

CN1N=CC(C2=NN3C(SC4=CC5=CC=CN=C5C=C4)=NN=C3C=C2)=C1

makes you wonder…

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Posted in c-Met, SGX | 8 Comments »

SGX-523

Posted by kinasepro on December 3, 2007

SGX just submitted an IND for their selective C-Met inhibitor SGX-523

recent webcast here

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