KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Granted’ Category

US7125875

Posted by kinasepro on October 26, 2006

The claims are basically: Swallow Dasatinib wherein the cancer is Gleevec resistant. Read the J Med Chems (here, and here). BMS has been prolific in writing about their aminothiazoles and there’s plenty of bioorg med chem lett’s too. For anyone who’s been living under a rock for the last couple years, Dasatinib is BMS’s SRC / ABL compound. They use the (cough*stupid*cough) term ‘pan-SRC selective’ since it hits: YES / LCK / LYN / FYN / etc.

…and thats just the profile they want to tell us about…

PDB = 2GQG

O=C(C2=CN=C(NC3=NC(C)=NC(N4CCN(CCO)CC4)=C3)S2)NC1=C(C)C=CC=C1Cl BMS35482513 Dasatinib

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Posted in bcr abl, BMS, Granted, SRC | Leave a Comment »

US7125888

Posted by kinasepro on October 26, 2006

Hi Merck, VEGFR2 Inhibitors?!

**yawns**

If my read is correct these sound like ‘pure’ VEGF compounds though. Ok thats interesting enough I guess, ocular indications, macular degeneration, yada-yada-yada. The patent claims the compounds in combination NSAIDs.

O=C1C=C(C4=CC3=NC=C(C5=CC=CC=C5)N3C=C4)C=CN1CCCN2CCCCC2

Posted in Granted, Merck & Co., VEGF | Leave a Comment »