KinasePro

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Archive for the ‘tpl2’ Category

TPL2 4 Real?

Posted by kinasepro on November 27, 2006

Hey Wyeth, so is TPL2 for real? I see people have been talking up Cot/TPL2/MAP3K8 as another tnf-α inhibiting kinase target, but it seems that nobody else (cept maybe Abbott) seems to have jumped on board yet.

Yes that is a chloride atom there hugging the hinge.

WO2006124692
WO2006124944

Bioorg Med Chem Lett 2006, 6067
Bioorg Med Chem Lett 2005, 5288
(unrelated Abbott tpl2 series: WO2005110410)

ps. Thanks T.S. for the tip that wipo search feature bears much to be loved.

Posted in tpl2, Wyeth | 3 Comments »