KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Nerviano’ Category

Postcards from Vienna…

Posted by kinasepro on October 1, 2008

Hey look what I got:

Yah, its the disclosure of the discovery of PHA-848125.  Not only that, its a pretty good poster. This also means I was wrong again!

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Posted in CDK, Nerviano | 7 Comments »

CDC7

Posted by kinasepro on October 4, 2007

Nerviano‘s got CDC7 inhibitors…

And they look something like:

O=C(C1=C(C2=CC(F)=CC=C2Cl)NC(C3=NC(N)=NC=C3)=C1)N

07/110344, 07/096334, 07/071621

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Nerviano ‘n CDK

Posted by kinasepro on August 19, 2007

>> Update >> its really PHA-848125

WO/2007/90794 is a CDK inhibitor in combination with yada yada… from Nerviano.  The single compound claimed is pictured and potentially the phase one compound: PHA-793887.

O=C(C1=NN(C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C23)NC

Discovery: Pharmacia IT WO/2004/104007

Posted in CDK, Nerviano | 4 Comments »

WO/2007/009898 (Nerviano)

Posted by kinasepro on January 31, 2007

Nerviano’s been looking at the thienopyrroles since the Pharmacia IT days, but the priority date on this one is 7/05… So whats new I ask? Well, appears they found some ortho substituents that work.

O=C(C(S1)=CC2=C1NN=C2NC(C3=CC=CC=C3N([H])C(C)=O)=O)NC(C4=CC=CC=C4)(C)C

Most notably amides and benzamides
Hmm… See a little quinazoline isostere in these?

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Aurora dev compounds

Posted by kinasepro on January 22, 2007

Crimson Canary has a Rockin spreadsheet on Aurora inhibitors in development.

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Posted in Aurora, Nerviano | 3 Comments »

Plethora ‘o’ PDB’s

Posted by kinasepro on November 15, 2006

6 good one’s released today:

2J50 PHA-739358 bound to Aurora-2 (Nerviano’s phase 1 compound)

O=C(NC1=C2C(CN(C([C@H](OC)C3=CC=CC=C3)=O)C2)=NN1)C4=CC=C(N5CCN(C)CC5)C=C4

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