Archive for the ‘General Interest’ Category
Posted by kinasepro on June 9, 2009
Just when you thought this stuff was easy… Turns out:
* Sorafenib hits P38 (new structure),
Posted by kinasepro on May 29, 2009
Structural Insights into Kinase Inhibition
More like this please!
Posted by kinasepro on May 25, 2009
So just what is an allosteric kinase inhibitor?
Posted by kinasepro on April 19, 2009
Send Structures / Will Post!
Email me smiles/inchi/chemdraw/iupac – whatever. Structure and a corporate number is good enough, but any other info – feel free. (please include whether you want to be anon)
Posted by kinasepro on March 16, 2009
Kinase-Blogging is rightly where it’s at these day’s
MoTD: Got: Sutent?
Biohealth Investor: Got Sutent Too.
OPD: Still makin’em
Shaji: Has something to say
And Sammy read a paper (though has peculiar taste in music.)
to celebrate I’ll be hitting the post button a couple times over the next few days.
Posted by kinasepro on November 5, 2008
? ~ F(x) has some thoughts.
Ever since Captopril, I’ve always thought ‘rational design’ to be over-rated and over-sold. We can do an awful lot without pin-point accuracy, and frankly we don’t have to understand why something is safe and effective to make it so. Perhaps Ashutosh has tickled a nerve by bringing it up, but I fail to understand why people prefer this fanciful delusion of rational design to the reality of knowledge-based trial and error, but the primary literature is chock full-o-nuts claiming to be a lot smarter then they really are. But I digress…
On non-oncology indications, of course Fasudil was approved in Japan in 1995 for ‘vascular spasms in the brain’ or some suchness, and is in Ph3 in the US for a few indications. Pfizer and Incyte each have related Jak inhibitors which have looked promising in Ph2 studies. Otherwise your looking at Rigel’s Ph2 Syk / Flt3 / Vegf inhibitor R-788 also in trials for RA but more likely to be approved for more acute indications, and then there’s always the p38 inhibitors, like Array’s recent ph2, but who knows if and when this target will deliver.
The fact that there was a Kinase-related conference and nobody could rattle that off suggests I’m not posting enough…
Posted by kinasepro on October 23, 2008
Cool, yah ,so, umm, like, thats why they gotta be flat.