KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Bayer ‘n Egf

Posted by kinasepro on October 2, 2007

Set of covalent ErbB inhibitors from Bayer:

O=C(/C=C/CN(CC)C)N(CC3)CC2=C3C1=C(NC4=CC(C=CN5CC6=NC=CC=C6)=C5C=C4)N=CN=C1S2

WO/2007/109279

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3 Responses to “Bayer ‘n Egf”

  1. Is that an aniline I see? Heathens! Burn them!

  2. DrBaritone said

    Derived from benzyle indole/indazole patents, Glaxo Wellcome 1996. Think of something new!

    erbB irreversible inhibitors,….why?

  3. Radiochemist said

    Ever heard of specific mutations in the binding pocket leading to resistance to Iressa?

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