So what is going on with TGF-β anyhow. GSK WO/2002/062794 , Lilly WO/2002/094833, WO/2004/050659, & WO/2005/092894, Biogen WO/2004/072033, and Pfizer (WL) WO/2004/026306 have all been playing in the pyrazole / TGF sandbox but all I’ve seen is some pretty pictures and a few J. Med Chem.’s
Biogen’s got a new one with WO/2007/059359, but not a single mention in during “R&D day.” 😦 Its either supersekrit, or DOA.