Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Deals’ Category

News of the day

Posted by kinasepro on November 14, 2007


aetiology and limited data in: WO/2005/048953

Posted in Ambit, Aurora, Deals, Flt3, Rigel | 16 Comments »

Array: Bag ‘o’ cash en route

Posted by kinasepro on September 25, 2007

40M up front:

…Array will grant Celgene an option to select drugs developed under the collaboration that are directed to two of four mutually selected discovery targets

Looks like unpartnerds include: KSP, P38, P38/tie2, Erbb1-2RAF, TLR’s, etc

Posted in Array, Celgene, Deals | Leave a Comment »


Posted by kinasepro on April 27, 2007

Hard to spit in the sink at ‘30 million for the Asian rights‘ to a ph1 compound…



Posted in c-Met, Deals | Leave a Comment »


Posted by kinasepro on January 4, 2007

>> update >>   An Exelixis Mek application WO/2007/044515 published 4/19/07

So did the IND and deal actually beat the patent application? Either that or I’m missing something, because I can’t find it.

“XL518 is the second Exelixis compound designed to inhibit the RAS/RAF/MEK/ERK pathway with high potency and specificity, and the first to specifically target MEK,”

They’ve got an interesting RAF application in the stable, but I was under the impression that was the one to house the XL281 series.

hat tip: Xcovery, but of course.

Posted in Deals, Exelixis, Genentech, MEK | 2 Comments »

Wyeth gets Jak’d up!

Posted by kinasepro on December 30, 2006

via Jak3 but of course – in an underanounced deal with Pharmacopeia:

…Wyeth will pay Pharmacopeia $5 million initially, as much as $9 million of research funding over the next three years, and as much as $175 million for reaching certain goals with the JAK3 kinase inhibitor drug.

While it’s likely they have a few which haven’t published yet, WO/2006/108103 is the most recent PCOP Jak3 application.


They’ve been at this stuff for a while – I reckon since WO/2001/047921 and have a recent Tet Lett on a related series. Check 2HK5 for a clue on how they bind.

>> update 1/25/07 >> US20070021443 Jak3 Pharmacopeia patent application

Posted in Deals, JAK, Pharmacopeia, Wyeth | 3 Comments »