KinasePro

Kinase Chemistry – Just a year and a half behind the times.

PF-477736

Posted by kinasepro on October 12, 2007

PF-477736 is Pfizers phase 1 Chk1 inhibitor being given in combination with Gemcitabine. They haven’t confirmed the structure yet, but…

N[C@H](C5CCCCC5)C(NC4=CC1=C(C3=C4)C(C=NNC3=O)=C(C2=CN(N=C2)C)N1)=O

It just so happens that 2007/113671 covers the above Chk1 inhibitor in combination with chemotherapy.   It may be the wrong structure, but till proven thus, it’s on the list.  Click for selectivity.

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7 Responses to “PF-477736”

  1. Icecream said

    Looks like their PARP inhibitor AG-14699

  2. kinasepro said

    I wouldn’t have thought to look there… but your right.

  3. Sun said

    Hi, I would like to know where and how to get some TIE2 inhibitors, such as Abbot’s A-422885.66, or more recently GSK’s TIE2 inhibitor. I am an academic researcher and would like to test TIE2 inhibitor in our bio assays. Thanks.

  4. kinasepro said

    I think you have a few options…

    I would probably just make what I needed! But if that option isn’t available to you I might suggest the following path: 1) look for a commercial source (it doesn’t look good here as I don’t know of anything you’d be interested in that is available) 2) Email every contact on every tie-2 inhibitor related paper in the hopes that someone will be willing to go through the hassle of a material transfer agreement in order to collaborate with you [search scifinder for the CAS# of Tie-2]. 3) Take a few associate prof’s out to lunch and convince them of a new and rewarding opportunity to collaborate with your group by making some inhibitors 4) Dip into your grant money and have a CRO make compounds for you.

    Feel free to 5) Leave your email here and hope someone takes you up on the opportunity, or maybe even 6) If you’d like to make a more detailed request with what you’ll likely be doing with the compounds, send me an email and I’ll be happy to give you your very own post here at KinasePro.

  5. Did you check some of the commercial databases on Pubchem (such as the Chembridge and Asinex libraries)?

  6. superpotent said

    Another option for Sun in obtaining A-422885.66 is contact Abbott R&D folks directly – if you can generate some interest in your project there is possibility of collaboration and I’m sure they have boatloads of the compound.

  7. jerkel said

    Hi everybody,

    obviously it is a bit too late to come with you with a solution to your puzzling question, but at least from now on you know waht is the right structure of PF-477736.
    This compound is available in our library of compounds,
    visit the website of our company for more information : Axon Medchem.
    We are a CRO specialized in Medicinal Chemistry and we can deal with any synthesis you like.
    See you soon,
    Jerome

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