Kinase Chemistry – Just a year and a half behind the times.

AZ’s GSK3 Indolinone

Posted by kinasepro on August 10, 2007

WO/2007/089192 is a use app, and WO/2007/089191 is salt forms application of the pictured GSK3 inhibitor originally from WO/2003/08285.  The YM-231146 / YM-359445 series bears similarity, albeit for Vegf.


The PDB used for alignment is 1UV5, and you can also check out AZ’s publicized interest in selective GSK3 inhibition in an ’03 JBC and 1q5k.

2 Responses to “AZ’s GSK3 Indolinone”

  1. Had you posted this earlier with a few different words, or am I just having a sense of deja vu?

  2. kinasepro said

    Just added the YM series’

    original wording is still in googles cache though… heh.

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