KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AZ’s GSK3 Indolinone

Posted by kinasepro on August 10, 2007

WO/2007/089192 is a use app, and WO/2007/089191 is salt forms application of the pictured GSK3 inhibitor originally from WO/2003/08285.  The YM-231146 / YM-359445 series bears similarity, albeit for Vegf.

N#CC1=CC2=C(NC(/C2=C3C=CC(CN4CCOCC4)=CN\3)=O)C=C1

The PDB used for alignment is 1UV5, and you can also check out AZ’s publicized interest in selective GSK3 inhibition in an ’03 JBC and 1q5k.

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2 Responses to “AZ’s GSK3 Indolinone”

  1. Had you posted this earlier with a few different words, or am I just having a sense of deja vu?

  2. kinasepro said

    Just added the YM series’

    original wording is still in googles cache though… heh.

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