KinasePro

Kinase Chemistry – Just a year and a half behind the times.

PX-866

Posted by kinasepro on April 17, 2007

PX-866 is a Wortmannin analog that came to Biomira as part of the Prolx deal.

O=C1/C(C([C@]2(C)[C@@H](COC)O1)=C(O)C(C3=C2[C@H](OC(C)=O)C[C@@]4(C)[C@@]3([H])CCC4=O)=O)=C/N(CC=C)CC=C

You synthetic junkies should recognize at least one of the names on the patent app. Appears to be a simple improvement to the michael acceptor.

1E7U shows the natural product covalently bound to Pi3k

O=C1C2=COC3=C2[C@](C([C@H](OC(C)=O)C[C@]45C)=C([C@@]5([H])CCC4=O)C3=O)(C)[C@@H](COC)O1

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