KinasePro

Kinase Chemistry – Just a year and a half behind the times.

MLN-0415

Posted by kinasepro on May 2, 2009

Millenium’s beta-carboline’s aren’t new, but the structure of the Phase one IKK-B inhibitor hasn’t been released afaik.  Currrently in the Takeda pipeline via last years takeover.

ClC1=CC(NC([C@H]2N(CC(C)(OC2)C)CC(N3C[C@H](O[C@H](C3)C)C)=O)=O)=C(C4=C1)NC5=C4C=CN=C5WO/2009/054970

Previously being codeveloped with Sanofi, but I have’t found anything recent on that.

ClC1=CC(NC([C@H]2N(CC(C)(OC2)C)CC(N3C[C@H](O[C@H](C3)C)C)=O)=O)=C(C4=C1)NC5=C4C=CN=C5.ClC6=C(OC)C(NC(C7=CC=CN=C7C)=O)=C(C8=C6)NC9=C8C=CN=C9.BrC(C(OC)=CC=C%10%11)=C%10NC%12=C%11C=CN=C%12Initial hit’s a cousins of  Harmine

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