KinasePro

Kinase Chemistry – Just a year and a half behind the times.

RAF a la MLNM

Posted by kinasepro on July 4, 2007

US20070149533 is a Raf app from Millennium. I see it as a napthalene – amide cousin to the Birb and Nexavar style ureas. Amgen’s been in the area but not right on top.

O=C(CCN1CCN(C)CC1)NC2=NC=CC(OC3=CC(C=CC(C(NC4=CC(C(C)(C)C)=CC=C4)=O)=C5)=C5C=C3)=C2

Good thing too, b/c you know, I was’t really feeling the whole ‘hydrocinnamides’ thing in US20060160803

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