Posted by kinasepro on December 16, 2006
WTF J&J, Oxime-aldehydes? FLT3, TRKb, cKit inhibitors… Shinogi has some related EGF compounds: WO2006106721, and there’s a Biorg Med Chem Lett with the motif in CDK so its not unheard of. Quinazoline isosteres… Cool.
Update >> There’s a couple other relatives that make this a family of applications which all published last Thursday:
This looks like the primary series, and the aniline appears to dial in TRKB – albeit not all that dramatically: US20060281772
Hmm… is LG293 TRKb?