KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for May 12th, 2009

BI-6727

Posted by kinasepro on May 12, 2009

BI’s PhII follow on to BI-2536

O=C(N[C@H]1CC[C@H](N2CCN(CC3CC3)CC2)CC1)C4=CC=C(NC(N=C5N(C(C)C)[C@@H]6CC)=NC=C5N(C)C6=O)C(OC)=C4

PDB: 3FC2; Clin Can Res

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Posted in BI, Plk1 | Leave a Comment »

SNS-314

Posted by kinasepro on May 12, 2009

Sunesis’ Ph1 Aurora inhibitor:

O=C(NC1=NC=C(CCNC2=C3C(C=CS3)=NC=N2)S1)NC4=CC=CC(Cl)=C4
Related PDB’s: 3D15,3D14,3D2I,3DJ7
Amgen’s related pyrimidine: 3EFW

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Posted in Aurora, Sunesis | 1 Comment »

PF-04217903

Posted by kinasepro on May 12, 2009

This one snuck past me… and into the clinic.  Currently its Ph1 via: WO/2007/132308

OCCN(N=C1)C=C1C2=CN=C(N=NN3CC4=CC=C(N=CC=C5)C5=C4)C3=N2

this and PF-2341066 both still in the pipeline.

note also WO/2007/138472

Posted in c-Met, Pfizer | 1 Comment »