Astex’s fragment based discovery effort yielded an oral candidate back in ’05, and now with WO/2007/129066 & WO/2007/129062 the world can have a look. It’s probably AT-9311 even though I could’a swore I heard’m say that their Novartis’ partnered material was of a different series then AT-7519. Perhaps its 7519 I have wrong…
pM CDK2 |
0.22 uM GSK3b |
Mouse: 40-50%F (DMSO/Water/PEG 1/2/7) |