Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on September 3, 2008

Plexxikon’s Ph1 in healthy volunteers underway with plans for and pain and PKD. They’re not advertising the target, but my guess is c-fms. We’ve been following their earlier cFms / cKkit double-stuff, and its likely they found a group to tune out the Kit, maybe something like: WO/2008/080015

still no partner…


2 Responses to “PLX-5568”

  1. chalker said

    In the patent they talk about inhibiting TrkA as a treatment for pain so I reckon they have a FMS/cKit/TrkA inhibitor and are going for the TRKA indication which may be easier to achieve than chasing a FMS disease target. The 6 compounds that they claim have <1uM activity on TrkA are also <1uM on FMS and cKit.
    PS Good to have you back KP!

  2. kynase said

    The PR mentioned “Raf inhibitor”. This one does not seem to be “drug-like”.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: