KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Amgen ‘n’ IRAK-4

Posted by kinasepro on February 20, 2007

Irak-4? Yah I never heard of it either, but the IRAKs appear to be immunology targets for which Amgen is way out in front. They’ve got a nice paper in Structure, a Biorg. Med. Chem. Lett., and 2 PDB’s: 2NRU, 2NRY.

At first look I was mesmerized by the tyrosine gatekeeper but a second glance on looking over the recent CIP: US20070037803 shows something interesting.

O=C(C1=CC(C(F)(F)F)=CC=C1)\N=C2N([C@@H]3CC[C@@H](O)CC3)C4=CC=C(OCCN5CCOCC5)C=C4N/2

they suggest as much in the BMCL.

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One Response to “Amgen ‘n’ IRAK-4”

  1. One learns to identify that backbone binding motif almost by reflex action…

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