KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Merck & Co.’ Category

US20060270673

Posted by kinasepro on December 1, 2006

Hidy Ho Merck and Co., I’d say nice AKT inhibitors, but I notice you’re doing your xeno studies sub-q.

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Bioorg. Med. Chem. Lett. 2006, 5809

Posted by kinasepro on November 1, 2006

 

Hi Merck, Nice P38 patent BMCL describing the observed selectivity for VX-745 and related analogs. This is the companion article to: 2I0H

O=C1N(CCCN(C2=CC=C(F)C=C2Cl)C(C=C3)=NN(C4=CC=CC=C4Cl)C3=O)C(C5=C1C=CC=C5)=O

1M7Q droped the dime on this motif back in ’03

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US7125888

Posted by kinasepro on October 26, 2006

Hi Merck, VEGFR2 Inhibitors?!

**yawns**

If my read is correct these sound like ‘pure’ VEGF compounds though. Ok thats interesting enough I guess, ocular indications, macular degeneration, yada-yada-yada. The patent claims the compounds in combination NSAIDs.

O=C1C=C(C4=CC3=NC=C(C5=CC=CC=C5)N3C=C4)C=CN1CCCN2CCCCC2

Posted in Granted, Merck & Co., VEGF | Leave a Comment »