Kinase Chemistry – Just a year and a half behind the times.

Archive for the ‘Merck & Co.’ Category


Posted by kinasepro on December 1, 2006

Hidy Ho Merck and Co., I’d say nice AKT inhibitors, but I notice you’re doing your xeno studies sub-q.

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Bioorg. Med. Chem. Lett. 2006, 5809

Posted by kinasepro on November 1, 2006


Hi Merck, Nice P38 patent BMCL describing the observed selectivity for VX-745 and related analogs. This is the companion article to: 2I0H


1M7Q droped the dime on this motif back in ’03

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Posted by kinasepro on October 26, 2006

Hi Merck, VEGFR2 Inhibitors?!


If my read is correct these sound like ‘pure’ VEGF compounds though. Ok thats interesting enough I guess, ocular indications, macular degeneration, yada-yada-yada. The patent claims the compounds in combination NSAIDs.


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