Kinase Chemistry – Just a year and a half behind the times.

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Posted on May 17, 2007

Supergen just gave an update in Italy yesterday: webcast here. Skip to ~7 minutes for the kinase portion. The highlight for me is on MP-470 where he says that its uM on met (and ret). but at AACR last year they suggested that: In their defence I’ll postulate that they meant 4,000 nM concentrations last […]

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Posted in biotech | 16 Comments »

clinical roundup

Posted on July 26, 2007

Supergen initiates dosing of flt3 inhibitor MP-470: ph1 ‘advanced-stage solid tumors.’ Entremed initiates trial for Aurora inihbitor MKC-1: Ph1 Leukemia Kinex gets the FDA go-ahead for Src inhibitor KX2-391: lymphoma or solid tumors (though despite the press release, it’s not the first non-atp competitive kinase inhibitor to enter the clinic. The MEK inhibitors were)

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