KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AT-131418

Posted by kinasepro on August 7, 2009

Astex has released data about their AKT program, including a PDB, but I have omitted that they appear to have dropped the strutcture of their candidate in WO/2008/110846

O[C@](CN)(C1=CC=C(Cl)C=C1)C(C=C2)=CC=C2C3=CNN=C3

Thanks, Ed.

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One Response to “AT-131418”

  1. anonymous1 said

    It is a bit cheeky to call it “AKT inhibitor” with similar or even better potency against PKA, p70SK and Rock.
    Patent itself covers the usage in conditions linked to either of those kinases !

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