Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on June 28, 2009

It’s a Ph1 Aurora A/B/C inhibitor for ‘solid tumors’.  Seems likely to be a member of one of the phthalazine series’ WO/2008/124083, WO/2008/057280, WO/2007/100646, or WO/2007/087276.


2 Responses to “AMG-900”

  1. Ed said

    Reckon this was designed along the lines of PTK787 + (Kirin?) quinoline sort of fragment linking, or is that way off base? As ligands go, I think it is perhaps uniquely ugly – more spinach required….

    I’ll take piss-poor solubility with concomitant VEGF mediated hypertension for $1000 please Alex

  2. kinasepro said

    can’t be way off, but the phthalazine is a bit farther away from the hinge.

    I disagree on the aethetic factor though. While it looks big, the drawn molecule is MW:500 and none of the bits can fall off…

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