KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Off Targets

Posted by kinasepro on June 9, 2009

Just when you thought this stuff was easy… Turns out:

* Gleevec & Nilotinib hit ‘α-carbonic anhydrase‘ (wiki). (not to mention p38ß)

* Sorafenib hits P38 (new structure),

* GW-5074 (cRaf inhibitor) weakly hits glutamate dehydrogenase (~2uM, new structure, wiki).

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